Sensitive, Direct and Rapid Spectrophotometric Method for the Determination of Meloxicam through Ion-Associate Complex Formation | ||
| Journal of Basic and Environmental Sciences | ||
| Volume 1, Issue 3, July 2014, Pages 92-101 PDF (489.56 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jbes.2014.369576 | ||
| Authors | ||
| M.A. Kasem1; H.E. Megahed1; M.E. Moustafa2; H.A. Ibrahim1 | ||
| 1Chemistry Department, Faculty of Science. Benha University, Benha, Egypt. | ||
| 2Chemistry Department, Faculty of Science. Benha University, Benha, Egypt | ||
| Abstract | ||
| A simple, accurate and sensitive spectrophotometric method has been developed and validated for the determination of meloxicam. The method is based on the formation of the ion-associate complexes between meloxicam and orange G (OG), methylene blue (MB) or copper chloride (CuCl2) to give colored products maximally absorbed at 358, 652, 361 nm, with the three reagents respectively. Different factors affecting the reaction between the drug and the three reagents were carefully studied and optimized. Under the optimum conditions, linear relationships with good correlation coefficients (0.9956, 0.9934 and 0.9974) were found between absorbance and concentrations of the drug in the concentration range 1.0-22.1 µgml-1 . The assay limits of detection and quantitation were in the ranges 0.40-1.73, 0.66- 1.87 and 0.8-1.33 µgml-1 , respectively. The method was validated, in terms of accuracy and precision and the results are satisfactory. The proposed method was successfully applied to the determination of the investigated drug in pure and pharmaceutical dosage forms (recovery is 99.63, 100.14 and 99.86 % for OG, MB and CuCl2 respectively) without interference from the common excipients. The results obtained by the proposed method were comparable with those obtained by reference methods. | ||
| Keywords | ||
| Meloxicam Spectrophotometric method Ion; associate complex | ||
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