Chemical and Bioactivity Studies on Salvia Africana-Lutea: Cytotoxicity and Apoptosis Induction by Abietane Diterpenes Isolated from Salvia Africana-Lutea | ||||
| Journal of Basic and Environmental Sciences | ||||
| Volume 5, Issue 1, January 2018, Page 72-79 PDF (554.78 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jbes.2018.369768 | ||||
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| Authors | ||||
| M.M.H. Arief1; Ahmed Abdel Fattah. Hussein2; Abdelhamid. Mohammed3; Hassan.M. ElMwafy4 | ||||
| 1Professor of Organic Chemistry, Benha University, Egypt | ||||
| 2Professor of Chemistry, National Research Centre, Cairo, Egypt. | ||||
| 3Professor of Marine, National Institute, Egypt. | ||||
| 4B.Sc. Chemistry Department, Benha University, Egypt | ||||
| Abstract | ||||
| Re-investigation of the phytochemical constituents of Salvia africana-lutea L. methanolc extract, led to the purification and identification of six abietane diterpene (7 -methoxyrosmanol (1), rosmadial (2), rosmanol (3), carnosol (4), epiisorosmanol (5), epirosmanol (6)) and rosmarinic acid methyl ester (7). The compounds 1 and 3-5 showed significant anti-proliferative effect on HT-29 and MCF-7 cells, additionally, 7 -methoxyrosmanal (1) found to induce apoptosis in colorectal adenocarcinoma cells. The apoptotic pathway is characterized by the activation of caspases cascade (viz caspase 9) which climaxed in caspase-3 activation. | ||||
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