Emergence and characteristics of the SARS-CoV outbreak from identification to cellular entry mechanism | ||||
| Journal of Applied Molecular Biology | ||||
| Volume 2, Issue 2 - Serial Number 2974, July 2024, Page 175-187 PDF (830.58 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jamb.2024.279990.1022 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Dalia Essam Zanaty   1; Omniaa Al-Badawy2; Manal Elkhwaga3; Mohamed A. El-Mokhtar 2
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| 1Molecular Biology and Research Studies Institute, Assiut University, 71516 Assiut, Egypt | ||||
| 2Medical Microbiology and Immunology Department, Faculty of Medicine, Assiut University, 71516 Assiut, Egypt | ||||
| 3Chest Department, Faculty of Medicine, Assiut University, 71516 Assiut, Egypt | ||||
| Abstract | ||||
| A number of Wuhan hospitals treated clusters of patients with pneumonia in late December 2019; the causes of these cases remain unknown. On January 30 The World Health Organization (WHO) recognized the ongoing coronavirus outbreak as a global public health emergency. The International Committee on Taxonomy of Viruses officially named the new coronavirus "SARS-CoV-2" on February 11, whereas the World Health Organization classified the disease as "COVID-19"." New research shows that SARS-CoV-2 uses the ACE2 receptor to access cells, working in tandem with the host's TMPRSS2. Research has discovered that cells that have a greater amount of ACE2 expression are more vulnerable to the SARS-COV S protein. This implies that higher levels of ACE2 could heighten the likelihood of SARS-CoV-2 infection. Although most coronaviruses affect birds, some can infect mammals as well.(2) Key stages in the infection process of SARS-CoV-2 in host cells involve the use of Ace2 and TMPRSS2.. As with other viruses, SARS-CoV-2 employs transmembrane serine protein 2 (TMPRSS2) as a major entry point into human cells. | ||||
| Keywords | ||||
| COVID; ace2; cell entry; tmprss2 | ||||
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