Skin level of microRNA-369-3P in patients with psoriasis and its correlation with disease severity | ||||
| Journal of Current Medical Research and Practice | ||||
| Volume 2, Issue 1, January 2017, Page 32-34 PDF (260 K) | ||||
| DOI: 10.4103/JCMRP.JCMRP_28_16 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Eman R. M. Hofny; Hanan Morsy; Ashraf Hasaballa; Howida Twisy | ||||
| Abstract | ||||
| Background Psoriasis is a common autoimmune skin disease characterized by intense proliferation and abnormal differentiation of keratinocytes. Recently, some microRNAs (miRs) have been proven to show an aberrant expression in psoriasis and may play a role in the pathogenesis of the disease. Objectives The aim of this study was to detect skin miR-369-3p levels in patients with psoriasis and its correlation with disease severity with measurement of one of its regulated psoriasis-related genes, , and to find the correlation between the studied parameters. Patients and methods Skin tissues were collected, and skin miR-369-3p and SIRT1 gene levels were measured. The Psoriasis Area and Severity Index scores of patients and the correlation with skin miR-369-3p levels were evaluated. Correlation between miR-369-3p and SIRT1 gene was also evaluated. Results Skin miR-369-3p levels were higher in patients with psoriasis than those in healthy controls ( = 0.01). Skin miR-369-3p had an insignificant positive linear relation with Psoriasis Area and Severity Index scores in psoriasis patients ( = 0.079, = 0.772). Insignificant negative correlation was found between miR-369-3p and SIRT1 gene levels in skin. Conclusion The expression of miR-369-3p is increased in skin tissues from psoriasis patients. Further studies are needed to clarify the role of miR-369-3p in the pathogenesis of psoriasis. | ||||
| Keywords | ||||
| microRNAs; microRNA-369-3p; Psoriasis Area and Severity Index; Psoriasis | ||||
|
Statistics Article View: 40 PDF Download: 90 |
||||
