Role of SCN1A, GABRA1, and GABRA2 in pathogenesis of febrile convulsions | ||||
| Journal of Current Medical Research and Practice | ||||
| Volume 6, Issue 4, October 2021, Page 379-383 PDF (268.38 K) | ||||
| DOI: 10.4103/jcmrp.jcmrp_69_21 | ||||
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| Authors | ||||
| Hamdy N. El Tallawy; Heba M. S. Eldin; Hisham M Imam; Ali M Bathalath; Mohamed M Shehab | ||||
| Abstract | ||||
| Aim The commonest seizure disorder in childhood are febrile seizures (FS). The aim of the study was to show the role of some genes (SCN1A, GABRA1, and GABRA2) in pathogenesis of the development of febrile convulsions. Patients and methods In total, 20 children from 6 to 60 months with FSs and 20 cross-matched healthy controls (regarding sex and age) were included in this study. Digital electroencephalogram was performed. The SCN1A (rs3812718 A/G), GABRA1 (rs2290732 A/G), and GABRA2 (rs 2298771 A/G) polymorphisms were analyzed by allelic discrimination Taqman assay. Results and conclusion Most of the patients developed FS at the age of 6 months–2 years (55%). About 40% of the patients had positive family history of FS. We did not find a significant difference between patients and controls in the three studied genes. Larger studies with a larger number of patients are needed to study these genes. | ||||
| Keywords | ||||
| febrile seizures; children; Genetic | ||||
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