Association of serum resistin level with albuminuria and estimated glomerular filtration rate in type 2 diabetes mellitus | ||
| Journal of Current Medical Research and Practice | ||
| Volume 7, Issue 1, January 2022, Pages 45-49 PDF (223.21 K) | ||
| DOI: 10.4103/JCMRP.JCMRP_45_20 | ||
| Authors | ||
| Nabawia Mahmoud Tawfik; Mohammed Hassan Mostafa; Amal M Mahmoud; Ahmed Osama Ibrahim | ||
| Abstract | ||
| Background Diabetes is a meta bolic disorder characterized by hyperglycemia, resulting from defects in insulin secretion, insulin action, or both. Resistin is described as a potential factor in obesity-mediated insulin resistance and type 2 diabetes mellitus. Aim To evaluate the relationship of resistin levels with estimated glomerular filtration rate (eGFR) and albuminuria in type 2 diabetic patients and to elucidate the role of resistin as an early biomarker for early detection of diabetic kidney disease. Patients and methods The study included 70 patients with type 2 diabetes mellitus, as well as 18 healthy participants as a control group who were age and sex matched with the patients. Serum resistin levels were assessed using an ELISA kit measured in ng/ml, albumin/creatinine ratio (ACR), eGFR by MDRD formula, and glycated hemoglobin (HbA1C). Results There was a significant positive correlation between serum resistin level and both HbA1C and ACR but a significant negative correlation with eGFR. Conclusion There was a significant increased level of HbA1C, resistin, and ACR (mg/g), whereas there was decreased level of eGFR in the patient group compared with the control group ( < 0.001). | ||
| Keywords | ||
| albuminuria; Glomerular Filtration Rate; Kidney diseases; Resistin | ||
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