Serum neutrophil gelatinase-associated lipocalin as a predictor of acute kidney injury in patients with coronary artery disease | ||||
| Journal of Current Medical Research and Practice | ||||
| Volume 7, Issue 1, January 2022, Page 50-55 PDF (653.36 K) | ||||
| DOI: 10.4103/jcmrp.jcmrp_57_21 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Madeeha Y. Bakheet; Basant R. Mohamed; Mohamed A. Ghany; Zeinab A. Abd Elhameed | ||||
| Abstract | ||||
| Background Acute kidney injury (AKI) after a percutaneous coronary intervention (PCI) is a major complexity. Early AKI diagnosis can help in treating this complication. Neutrophil gelatinase-associated lipocalin (NGAL) is a recent marker for the diagnosis of contrast-induced acute kidney injury (CI-AKI). This research targeted to evaluate the early diagnosis of CI-AKI and predictive value of NGAL and study the correlation between renal role tests and serum NGAL in cases with coronary artery disorder. Results In total, 11 (24.4%) patients had AKI, while 34 (75.6%) patients had no AKI. Serum urea NGAL was significantly greater in AKI cases either 2 or 48 h after PCI, while SCr was significantly greater in AKI cases 48 h after PCI. eGFR 48 h after PCI was significantly decreased in AKI patients. Albumin/creatinine (A/C) ratio was significantly greater in AKI cases. Serum NGAL 2 h after PCI positively correlated with A/C ratio and SCr 48 h after PCI, but is negatively correlated with eGFR 48 h after PCI. After 2 h, serum levels of NGAL had 90% sensitivity and 55% specificity; after 48 h, they had 81% sensitivity and 61% specificity. SCr after 2 h had 63% sensitivity and 82% specificity, and after 48 h, had 90% sensitivity and 88% specificity. Conclusion Serum NGAL can represent a sensitive early predictor biomarker for kidney damage after PCI. | ||||
| Keywords | ||||
| Acute kidney injury; Coronary Artery Disease; Neutrophil gelatinase-associated lipocalin | ||||
|
Statistics Article View: 19 PDF Download: 16 |
||||
