Role of matrix metalloproteinase-9 expression in the pathogenesis of early-onset preeclampsia | ||||
| Journal of Current Medical Research and Practice | ||||
| Volume 7, Issue 2, April 2022, Page 112-115 PDF (354.44 K) | ||||
| DOI: 10.4103/jcmrp.jcmrp_84_21 | ||||
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| Authors | ||||
| Ahmed M. Abbas; Fatma Youssef; Asmaa M. S. Gomaa; Eman S.H. Abd Allah; Marwa A. Ahmed | ||||
| Abstract | ||||
| Context Preeclampsia (PE) is a pregnancy disorder characterized by impaired invasiveness of the placenta in which matrix metalloproteinases (MMPs), especially MMP-9, play an important role. Aim To investigate the expression of MMP-9 in the placenta of patients with early-onset preeclampsia (EOPE) compared with controls. Setting and design The study included 50 pregnant women programmed for termination of pregnancy at a gestational age of 28–36 weeks. Women were divided into two groups: severe EOPE group ( = 30) and healthy pregnant control group ( = 20). Patients and methods A tissue was cut off from the center of the placenta, and the tissue was preserved for subsequent MMP-9 expression by real-time quantitative PCR. Results Neonatal and placental weights were significantly higher in the control group (P < 0.001). MMP-9 mRNA was significantly higher in the placentae of the control group compared with that of the preeclampsia group ( < 0.001). Conclusion MMP-9 expression in the placenta was significantly downregulated in patients with EOPE compared with normal pregnant women, suggesting their important role in trophoblast invasion. | ||||
| Keywords | ||||
| matrix metalloproteinase; preeclampsia; Pregnancy | ||||
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