Fetuin-A: a possible link between Helicobacter pylori infection and insulin resistance | ||
| The Scientific Journal of Al-Azhar Medical Faculty, Girls | ||
| Volume 3, Issue 2, May 2019, Pages 446-456 PDF (1.8 M) | ||
| DOI: 10.4103/sjamf.sjamf_53_19 | ||
| Authors | ||
| Huda M El-Sayed; Zeinab H El-Sayd; Tarek G Megahed; Mohammed M. Abd El-Wahab H El-Nabi | ||
| Abstract | ||
| Introduction infection has been associated with many extragastrointestinal diseases such as cardiovascular and neurological diseases. Recently, several studies have reported a relationship between nonalcoholic fatty liver disease and infection. Indeed, infection is involved in the pathogenesis of insulin resistance (IR), which is closely linked with nonalcoholic fatty liver disease. Furthermore, fetuin-A has been linked with impaired insulin sensitivity. Aim Therefore, we aimed to evaluate fetuin-A as a possible link between infection and IR. Patients and methods A total of 160 patients included in our study were divided into two groups according to the presence or absence of infection. We determined serum fetuin-A, serum insulin, homeostasis model assessment-IR, and liver and kidney functions. Upper gastrointestinal tract endoscopy and antral biopsy was taken for examination. Results We found that fetuin-A was significantly elevated in -positive group when compared with -negative group, and a significant positive correlation of fetuin-A was observed with fasting insulin levels and homeostasis model assessment-IR. Conclusion We conclude that fetuin-A was implicated as a possible link between infection and the development of nonalcoholic steatohepatitis through its effect on IR. | ||
| Keywords | ||
| Fetuin-A; Insulin Resistance | ||
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