Effect of Vascular Disrupting Agent (CA-4DP) and Ionizing Radiation on Tumor Growth in Rats | ||||
| Journal of Basic and Environmental Sciences | ||||
| Volume 6, Issue 2, April 2019, Page 97-103 PDF (499.15 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jbes.2019.370595 | ||||
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| Authors | ||||
| Z. M. Alghzzawy* 1; T. K. Elmaghraby1; S. A. Hagag1; M. H. Awwad2 | ||||
| 1National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority | ||||
| 2Faculty of Science, Benha University | ||||
| Abstract | ||||
| Hepatocellular carcinoma (HCC) is the most common primary liver cancer worldwide. This study was performed to explore the effect of low dose γ-irradiation (LDR) and Combretastatin A-4 disodium phosphate (CA-4DP) on HCC induced by N-nitrosodiethylamine (NDEA) in rats. Male Wistar albino rats were orally administrated NDEA for 17 weeks. Rats bearing HCC were intravenously injected with 10 mg/kg of CA-4DP and/or exposed to 0.20 Gy of γ-irradiation. Histopathological examination of the liver tissues was performed following 6, 24, and 48 h post CA-4DP injection. Treatment with LDR and CA-4DP resulted in extensive bleeding and necrosis in tumor tissue that was associated with HCC regression. The presented study demonstrated the promising therapeutic advantage of LDR along with CA-4DP in HCC. | ||||
| Keywords | ||||
| Hepatocellular carcinoma; Ionizing radiation; Combretastatin A-4 disodium phosphate. | ||||
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