PGT-A: Yes versus No | ||
Journal of Reproductive Medicine and Embryology | ||
Article 2, Volume 1, Issue 2, July 2024, Pages 74-86 PDF (360.23 K) | ||
Document Type: Debate | ||
DOI: 10.21608/jrme.2024.307483.1016 | ||
Authors | ||
Hisham Saleh* 1, 2, 3; Nehal Adel3, 4 | ||
1Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt. Egypt. | ||
2Agial Fertility Center, Agial Hospital, Alexandria, Egypt. | ||
3Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt. | ||
4Madina ICSI Fertility Center, Madina women's hospital, Alexandria, Egypt. | ||
Abstract | ||
The goal of In Vitro Fertilisation is a healthy full-term fetus. Still ART remains inefficient. The selection of embryos for transfer is based mainly on morphology. Morphology alone cannot select the embryo with the highest implantation potential. About 60% of early human embryos are aneuploid, and it increases dramatically with increasing maternal age.Embryo aneuploidy is the leading cause of implantation failure and miscarriage after IVF. Aneuploidy screening through taking a biopsy from the morphologically normal embryos & analysis of the embryo DNA allows to deselect embryos with abnormal chromosomal number. Aneuploid embryos are unable to self-correct. The proposed benefit is to improve embryo selection over morphological assessment to enhance the likelihood that a transferred embryo would result in a healthy live birth. Despite its worldwide use, PGT-A has faced many challenges and concerns from opponents regarding its value, accuracy, validity, cost effectiveness. Several fundamental questions must be answered in this regard. | ||
Keywords | ||
PGT-A; Aneuploidy; Euploid; Pros; Cons | ||
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