EFFECT OF THE PYRETHROID INSECTICIDE CYPERMETHRIN ON FERTILITY IN MALE RATS | ||||
| Veterinary Medical Journal (Giza) | ||||
| Volume 47, Issue 3, July 1999, Page 295-305 PDF (4.35 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/vmjg.1999.370853 | ||||
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| Authors | ||||
| MENHA ABD EL- KHALEK1; NARIMAN RAHMY2; H HALEEM3 | ||||
| 1Animal Health Research Institute Dokki-Giza, Toxicology unit | ||||
| 2Animal Health Research Institute Dokki-Giza, Pathology unit. | ||||
| 3Animal Health Research Institute Dokki-Giza, Toxicology unit. | ||||
| Abstract | ||||
| The effect of cypermethrin (ectomin) at two dos- age level on male reproductive organs were studied, the tested doses 1/40 and 1/30 LDs0, respectively were given for 65 successive days to male rats. Sex organ weight, semen picture, testosterone level were the criteria used to evaluate the productive efficiency of the treated male rats. Both doses decreased the weights of most genital organs, sperm cell concentration, percentage of live sperm, sperm motility and increased the percentage of total sperm, abnormalities. A decrease in the plasma testosterone level was observed in all treated groups. After 65 days on treatment and 30 days after last dose of drug administration as “compared to control group. Histopathological examiantion was carried out on testes and accessory glands (prostate and seminal vesicle) there was incomplete Spermatogenic process in the most of semineferous tubules, and activaiton of epithelial cell lining prostatic acini with polps formation protruded in the lumenae with cystic formation, while seminal vesicle showed cystic deilatation with polyps formation these changes were more potent in the large dose. | ||||
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