The Prospective Impact of Pennyroyal ( Mentha pulegium L.)and Calendula (Calendula officinalis L.) on Cyclosporine-A Induced Immunodeficiency in Male Rats | ||||
| مجلة بحوث التربية النوعية | ||||
| Volume 2024, Issue 83, May 2024, Page 241-280 PDF (821.83 K) | ||||
| Document Type: مقالات علمیة محکمة | ||||
| DOI: 10.21608/mbse.2024.286007.1451 | ||||
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| Authors | ||||
لمياء دياب   ; سماح البنا
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| قسم التغذية وعلوم الأطعمة، كلية الاقتصاد المنزلي، جامعة المنوفية، شبين الكوم، مصر | ||||
| Abstract | ||||
| This study aimed to identify the effect of aqueous extract of pennyroyal, calendula, and mixture of them on immunodeficiency in rats induced by cyclosporine (CsA). Thirty male albino rats weighing 150 ± 10g were used. For a week, each rat was fed a basel diet as a period of adaptation. Then, the rats were randomly selected and separated into two main groups, animals of the first main group (n=6 rats) were kept as a control negative group. The second main group (n=24) administered orally with a daily single dose 20mg/Kg/day from CsA for 21days and then, separated into four subgroups. The first sub group retained as a control positive group. The other three subgroups with immunodeficiency rats were treated with (50 mg aqueous extract /kg BW) pennyroyal, calendula and mixture of them (in the rate of 1:1), respectively. After 28 days, biological, biochemical and histological parameters assessment. The final results demonstrated that there was a significant enhance in FI, BWG, FER, LRW, SRW, IgA, IgG, IgM, HB, WBC.s, RBC.s, lymphocytes, neutrophils, PLT, SOD, CAT, IFN- γ, IL-6, TNF-α, and there was a significant minimize in MDA. The biochemical results were supported by histopathological examination. The group fed a mixture of calendula and pennyroyal (50 mg aqueous extract /kg BW) showed the best effects. It could be concluded that administration with pennyroyal and calendula aqueous extract improves biological parameters, immune system functions, oxidative stress, improve hematological parameters, improve cytokines level and improve the appearance of spleen tissue. | ||||
| Keywords | ||||
| Marigold; pulegone; quercetin; immune | ||||
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