A Study on the possible protective effects of angiotensin II type I receptor blocker (telmisartan) versus vitamin B12 on male albino rat model of Alzheimer | ||||
| Zagazig University Medical Journal | ||||
| Article 34, Volume 30, Issue 7, October 2024, Page 3540-3552 PDF (1.3 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.305435.3483 | ||||
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| Authors | ||||
Abeer A. Saeed; Mai Ahmed Elhady Attia Harf  ; Shereen El-Arabi Bdeer; Hadeel Aiman Elsherbini
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| Physiology Department, Faculty of Medicine, Zagazig university | ||||
| Abstract | ||||
| Background: Alzheimer's disease (AD) is regarded as one of the most common neurodegenerative diseases. It is a chronic, slowly progressing neurological illness that inhibits memory, cognition, and behavior. Objectives: This research aimed to evaluate the protective effect of angiotensin II type I receptor (AT1R) blockers versus vitamin B12 (VB12) on the AD rat model. Materials and methods: Thirty adult local strain male albino rat were randomly subdivided into 5 equal groups: Group I (control): vehicle only. Group II (AlCl3 induced AD group): AlCl3 175 mg/kg orally. Group III: telmisartan + AlCl3, Group IV: vitamin B12 + AlCl3, and Group V: vitamin B12 + telmisartan + AlCl3. Modified T maze test was used to evaluate the animal behavior. Rotarod test was employed to assess the animal muscle strength. In addition, serum and hippocampal level of brain derived neurotropic factor (BDNF) were assessed. Also, serum level of MDA and SOD were measured. Additionally, histopathological examination of hippocampus and brain tissue was performed Results: AlCl3 administration resulted in changes similar to AD as proved by deterioration in behavioral tests, significant reduction in serum and hippocampal BDNF, serum SOD and significant increase in serum MDA level along with corresponding histopathological changes in hippocampus. Furthermore, vitamin B12 and telmisartan ameliorated the previously measured chemical biomarkers and behavioral parameters. Conclusion: Angiotensin type 1 receptor blockade by telmisartan and vitamin B12 administration each one alone or both in combination could have a potential prophylactic and/or therapeutic effect in AD. | ||||
| Keywords | ||||
| protective effects; angiotensin II type I receptor blocker; telmisartan; vitamin B12; Alzheimer | ||||
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