BONE MARROW MICRO-METASTASES IN CLINICALLY STAGE I-III HER2/NEU POSITIVE BREAST CANCER | ||||
| The Egyptian Journal of Surgery | ||||
| Volume 27, Issue 3, July 2008, Page 132-140 PDF (1.44 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejsur.2008.371206 | ||||
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| Authors | ||||
| Sherif Reffat* 1; Soliman El-Kamash1; Amany Moustafa2; Hanaa Fahmy2; Aalaa Saad2; Fikry Goubran2 | ||||
| 1Department of surgery, Faculty of Medicine, Suez Canal University, Egypt | ||||
| 2Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Egypt | ||||
| Abstract | ||||
| Aim: Patients with breast cancer should have a favorable outcome when diagnosed early. Occult distant metastases, especially in the Bone Marrow (BM) was claimed to be responsible for tumor relapse in certain cases, especially in HER-2/neu expressing tumors. Such an occult metastases may be detected by PCR techniques for a BM aspirate, which is the aim of this study. Methods: Between May 2004 and May 2005, PCR technique was used to determine the tumor HER-2/neu status of 37 patients, attending Suez Canal University Hospital for the treatment of stage I-III breast cancer. BM and peripheral blood of those positive patients were examined by the same technique for the presence of micro-metastases. Correlation between tumor characteristics and the HER-2/neu status was done. Results: Fifteen patients were tumor HER-2/neu positive, which correlated with stage and number of positive lymph nodes. BM micro-metastases were detected in 7 patients, with no correlation to the tumor characteristics. Additionally, HER-2/neu positive tumor cells were detected in the peripheral blood of 6 patients. Conclusion: BM micro-metastases can be detected in HER-2/neu positive non-metastatic breast cancer that may be predicted by the peripheral blood not the primary tumor characteristics | ||||
| Keywords | ||||
| Disseminated tumor cells; Occult metastases; C-erbB2 | ||||
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