The Effect of Ginseng on Streptozotocin Induced Diabetic Cardiomyopathy in Male Rats | ||
| The Medical Journal of Cairo University | ||
| Volume 92, Issue 06, June 2024 PDF (172.84 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/mjcu.2024.371315 | ||
| Author | ||
| HEBA S. SHOUKRY, Ph.D. . | ||
| The Department of Medical Physiology, Physiology, Faculty of Medicine, Cairo University | ||
| Abstract | ||
| Background: Diabetes is considered one of the most com-mon metabolic disorders world wide. Diabetic cardiomyopathy is considered a great complicationassociated with diabetes that can affect patients causing mortality and morbidity. Ginseng is one of natural products used in complementary medicine. Aim of Study: The present study aimed to find out the ef-fect of ginseng on diabetic heart and the possible underlying mechanisms. Material and Methods: Adult male albino rats with body weights of 180 ~ 200g were introduced in the study; they were divided into: Control normal, Diabetic group, Diabetic + gin-seng. At the end of the study blood samples were collected for estimation of blood glucose, insulin, fatty acids, cardiac en-zymes, beta catenin, IL-6, caspase 3, glutathione peroxidase and reduced glutathione. Cardiac tissue was collected for his-tological analysis. Results: Results showed deterioration in all parameters in diabetic group while on administration of ginseng all param-eters were improved. Conclusion: Ginseng improved diabetic cardiomyopathy and prevents further cardiac deterioration. | ||
| Keywords | ||
| Ginseng; Cardiomyopathy; IL-6; Caspase3; Glutathione | ||
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