Gastric signet ring cell adenocarcinoma associated with Menetrier’s disease: a rare North African female case report
Belkralladi, H., Merad, Z., Sellam, F., Tou, A. (2024). Gastric signet ring cell adenocarcinoma associated with Menetrier’s disease: a rare North African female case report. EKB Journal Management System, 7(1), 185-196. doi: 10.21608/ajgh.2024.291022.1054
Houria Belkralladi; Zakaria Merad; Feriel Sellam; Abdelnacer Tou. "Gastric signet ring cell adenocarcinoma associated with Menetrier’s disease: a rare North African female case report". EKB Journal Management System, 7, 1, 2024, 185-196. doi: 10.21608/ajgh.2024.291022.1054
Belkralladi, H., Merad, Z., Sellam, F., Tou, A. (2024). 'Gastric signet ring cell adenocarcinoma associated with Menetrier’s disease: a rare North African female case report', EKB Journal Management System, 7(1), pp. 185-196. doi: 10.21608/ajgh.2024.291022.1054
Belkralladi, H., Merad, Z., Sellam, F., Tou, A. Gastric signet ring cell adenocarcinoma associated with Menetrier’s disease: a rare North African female case report. EKB Journal Management System, 2024; 7(1): 185-196. doi: 10.21608/ajgh.2024.291022.1054

Gastric signet ring cell adenocarcinoma associated with Menetrier’s disease: a rare North African female case report

African Journal of Gastroenterology and Hepatology
Volume 7, Issue 1, 2024, Page 185-196  XML PDF (719.85 K)
Document Type: Case Reports
DOI: 10.21608/ajgh.2024.291022.1054
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Authors
Houria Belkralladi1; Zakaria Merad1; Feriel Sellam email 2; Abdelnacer Tou1
1Department of Pathology, Sidi Bel Abbes University Hospital. Faculty of Medicine, Djilali Liabes University, Algeria.
2Laboratory of genetic diagnosis and microscopy platform, Biotechnology and Health Division, National Biotechnology Research Center, Constantine, Algeria.
Abstract
Background
 Menetrier's disease is an uncommon disease characterized by diffuse hypertrophy of gastric mucosa and giant gastric rugae with an increased risk of gastric cancer. Only a few reports supporting its association with gastric cancer have been found.
Material and methods
We present the case of signet ring cell adenocarcinoma associated with Menetrier's disease. The patient is a 54-year-old Algerian female.
Results
A 54-year-old woman was admitted to our hospital with a history of anemia, anorexia, and 10 kg weight loss. During her hospitalization, the patient presented an extradural hematoma. A biopsy was performed, which revealed a bone metastasis of the carcinomatous process. Abdominal computed tomography demonstrated diffuse thickening of the gastric wall. A gastric biopsy specimen showed thickened gastric mucosa and cystic dilatation of glands compatible with Menetrier's disease and diffuse infiltration by signet ring cell adenocarcinoma. A total gastrectomy was performed.
Conclusion
A patient with signet ring cell adenocarcinoma associated with Menetrier's disease is reported in our case study.
Keywords
Menetrier's disease; signet ring cell adenocarcinoma; gastrectomy; gastric cancer; woman
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