Serum Leptin and Nitric Oxide in Chronic Obstructive Pulmonary Disease | ||||
| Bulletin of Egyptian Society for Physiological Sciences | ||||
| Article 25, Volume 27, Issue 1, June 2007, Page 393-402 PDF (134.16 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/besps.2007.37177 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Mohamed Abd-elmoety* 1; Ismail Mohamed2 | ||||
| 1Department of Biochemistry, Sohag Faculty of Medicine, Sohag University | ||||
| 2Department of Chest Diseases, Sohag Faculty of Medicine, Sohag University | ||||
| Abstract | ||||
| Unexplained weight loss is common in patients with chronic obstructive pulmonary disease (COPD). Leptin not only is a critical regulator of body weight and appetite, but also serves as an immune-modulator. Nitric oxide (NO) is a potent relaxant of bronchial and pulmonary artery and leptin has a regulatory role in its synthesis. In the present study, the association of serum leptin levels with nitric oxide metabolites (NO) in COPD was investigated. Methods: Serum leptin and NO levels were measured in COPD patients [males (n=18) and females (n=15)] above forty years old compared with control group (n=30) in the same age matched group. Serum leptin levels were measured by enzyme linked immune sorbant assay (ELISA) technique. NO level was measured by spectrophotometric method. Results: Serum mean leptin level was significantly lower in COPD male group (9.7 ± 4.1 pg/ml) and female group (11.1 ± 3.7pg/ml) than corresponding control group (male: 12.7 ±1.4 pg/ml and female: 15.1 ± 1.5pg/ml) ( p <0.01 in both). Also, serum nitric oxide (nitrite and nitrate) in COPD male (18.4 ± 3.7μmol/L) and female group (15.9 ± 5.6 μmol/L) which was lower than corresponding control group (male: 21.2 ±1.9μmol/L and female: 24.2 ± 2.5μmol/L) (p <0.01 in both). Conclusions: low serum leptin associated with COPD is related with low BMI. Associated low nitric oxide serum level may be related to the pathogenesis of COPD. | ||||
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