A study on antiviral efficacy of Brucella abortus ether extract against experimental rabies infection in mice | ||
| Journal of Current Veterinary Research | ||
| Article 3, Volume 9, Issue 1, 2015, Pages 14-21 | ||
| Document Type: Original Article | ||
| DOI: 10.21608/jcvr.2015.37178 | ||
| Authors | ||
| Nermeen Shafik1; Hanan Mahmoud2; A. M. Albehwar* 3 | ||
| 1Central Laboratory for Evaluation of Veterinary Biologics, Abassia Cairo, Egypt | ||
| 2Central Laboratory for Evaluation of Veterinary Biologics, Abassia Cairo. | ||
| 3Veterinary Serum and Vaccine Research Institute, Abassia Cairo. | ||
| Abstract | ||
| The present work deals with Bru-Pel extract in a trial to investigate its effect against rabies virus. The obtained results revealed that Bru-pel has the affinity to induce the highest level of interferon when inoculated 8 hours pre-exposure to rabies infection. However it has no antiviral effect against rabies virus in mice when administrated pre and post-exposure to experimental infection even on zero time. So, it could not be used as post-exposure treatment in case of rabies infection. It was preferable to use specific antiserum with rabies vaccine in emergency cases (post-exposure) for providing the highest rate of protection when administrated on the suitable time (0 to 3 days post-exposure). | ||
| Keywords | ||
| Bru-Pel extract; Brucella; Rabies vaccine and Mice | ||
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