Preparation of Isatin/chitosan Schiff Base as Novel Antibacterial Biomaterials
Omer, A., Ammar, Y., Mohamed, G., Abd elbaky, Y., Tamer, T. (2019). Preparation of Isatin/chitosan Schiff Base as Novel Antibacterial Biomaterials. EKB Journal Management System, 62(Special Issue (Part 1) Innovation in Chemistry), 123-131. doi: 10.21608/ejchem.2019.7766.1614
Ahmed M. Omer; Y A Ammar; Gamil A Mohamed; Yasser S Abd elbaky; Tamer M Tamer. "Preparation of Isatin/chitosan Schiff Base as Novel Antibacterial Biomaterials". EKB Journal Management System, 62, Special Issue (Part 1) Innovation in Chemistry, 2019, 123-131. doi: 10.21608/ejchem.2019.7766.1614
Omer, A., Ammar, Y., Mohamed, G., Abd elbaky, Y., Tamer, T. (2019). 'Preparation of Isatin/chitosan Schiff Base as Novel Antibacterial Biomaterials', EKB Journal Management System, 62(Special Issue (Part 1) Innovation in Chemistry), pp. 123-131. doi: 10.21608/ejchem.2019.7766.1614
Omer, A., Ammar, Y., Mohamed, G., Abd elbaky, Y., Tamer, T. Preparation of Isatin/chitosan Schiff Base as Novel Antibacterial Biomaterials. EKB Journal Management System, 2019; 62(Special Issue (Part 1) Innovation in Chemistry): 123-131. doi: 10.21608/ejchem.2019.7766.1614

Preparation of Isatin/chitosan Schiff Base as Novel Antibacterial Biomaterials

Egyptian Journal of Chemistry
Article 10, Volume 62, Special Issue (Part 1) Innovation in Chemistry, December 2019, Page 123-131  XML PDF (1.18 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2019.7766.1614
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Authors
Ahmed M. Omer1; Y A Ammar2; Gamil A Mohamed3; Yasser S Abd elbaky4; Tamer M Tamer email orcid 5
1Polymer Materials Research Department, Advanced Technology and New Materials Research Institute, City for Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, P.O: Box: 21934, Alexandria, Egypt
2Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt, email: yossry@yahoo.com
32Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt
4City of Scientific Research and technological applications (SRTA
5City of Scientific Research and technological applications (SRTA)
Abstract
The research on biopolymers and its derivatives has received much attention from the researchers toward preparing a novel material. The biopolymers and its derivatives have broad applications due to its biodegradability, nontoxicity and biocompatibility. The present study aimed to develop and characterizes a unique chitosan Schiff base by coupling chitosan with isatin under acidic conditions to form isatin/chitosan Schiff base. The changing in chitosan chemical structure was proved by FT-IR, electronic spectra. The physico-chemical study shows a decrease of samples water uptake and solubility in aqueous acidic solution by increased isatin content as a result of an increase in hydrophobicity character of chitosan by modification. Antibacterial activity was tested against four different bacterial strains one gram-positive: (Staphylococcus aureus) and three gram negative (Pseudomonas aeruginosa, Salmonella and Proteus vulgaris). The results showed increases in the antibacterial activity of substituted chitosan against both gram-negative and gram-positive bacteria by the rise in isatin content.
Keywords
Chitosan; Isatin; Schiff base; Antibacterial activity
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