Preparation of Isatin/chitosan Schiff Base as Novel Antibacterial Biomaterials | ||
Egyptian Journal of Chemistry | ||
Article 10, Volume 62, Special Issue (Part 1) Innovation in Chemistry, December 2019, Pages 123-131 PDF (1.18 M) | ||
Document Type: Original Article | ||
DOI: 10.21608/ejchem.2019.7766.1614 | ||
Authors | ||
Ahmed M. Omer1; Y A Ammar2; Gamil A Mohamed3; Yasser S Abd elbaky4; Tamer M Tamer* 5 | ||
1Polymer Materials Research Department, Advanced Technology and New Materials Research Institute, City for Scientific Research and Technological Applications (SRTA-City), New Borg El-Arab City, P.O: Box: 21934, Alexandria, Egypt | ||
2Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt, email: yossry@yahoo.com | ||
32Chemistry Department, Faculty of Science, Al-Azhar University, Nasr City 11884 Cairo, Egypt | ||
4City of Scientific Research and technological applications (SRTA | ||
5City of Scientific Research and technological applications (SRTA) | ||
Abstract | ||
The research on biopolymers and its derivatives has received much attention from the researchers toward preparing a novel material. The biopolymers and its derivatives have broad applications due to its biodegradability, nontoxicity and biocompatibility. The present study aimed to develop and characterizes a unique chitosan Schiff base by coupling chitosan with isatin under acidic conditions to form isatin/chitosan Schiff base. The changing in chitosan chemical structure was proved by FT-IR, electronic spectra. The physico-chemical study shows a decrease of samples water uptake and solubility in aqueous acidic solution by increased isatin content as a result of an increase in hydrophobicity character of chitosan by modification. Antibacterial activity was tested against four different bacterial strains one gram-positive: (Staphylococcus aureus) and three gram negative (Pseudomonas aeruginosa, Salmonella and Proteus vulgaris). The results showed increases in the antibacterial activity of substituted chitosan against both gram-negative and gram-positive bacteria by the rise in isatin content. | ||
Keywords | ||
Chitosan; Isatin; Schiff base; Antibacterial activity | ||
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