Hormonal and Genetic Controls of Hirsutism: Link Between hyperprolactinemia, Polycystic ovary syndrome and Hirsutism | ||||
| Journal of Medical and Life Science | ||||
| Volume 6, Issue 3, September 2024, Page 283-293 PDF (1.2 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jmals.2024.372239 | ||||
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| Authors | ||||
Zainab Zamil Gataa Allami  1; Maytham A. Dragh1; Salah H. Faraj1; Rana S. Jawad2
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| 1Department of Biology, College of Science, University of Misan, Maysan, Iraq | ||||
| 2Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq | ||||
| Abstract | ||||
| The definition of hirsutism is when a woman has dark, thick hair that resembles men on her neck, face, chest, and in between thighs. The pathophysiology of hirsutism has been linked to some causes, such as genetic and hormone factors. It has been demonstrated that several such variables contribute to the development of hirsutism. The development of effective hyperprolactinemia for hirsutism diseases has relied on an understanding of the physiological roles and mechanistic functionalities of prolactin and hyperprolactinemia in hirsutism disease. Prolactin was reported to be effective through its action on DHEA and DHEA sulfate levels. The prolactin hormones have been described as affecting the hepatic synthesis of SHBG, simulating the actions of LH, and increasing both ovarian testosterone and adrenal DHEA-S production. The presented review aims to offer the most recent research on the possible roles of hormones and genes, their impacts on hirsutism, and the function of Reactive oxygen species (ROS) in the pathophysiology of polycystic ovary syndrome (PCOS). This review examines hormonal and genetic in human hair growth disorder. A focus is made on disorders of well-established genetic and hormonal origin. Such as hirsutism. Reviewed confirms that a complex interaction between hormones, genes, and ROS may underlie the differential of PCOS and hirsutism between patients and the healthy. | ||||
| Keywords | ||||
| Hyperprolactinemia; Polycystic ovary syndrome; ROS; Hirsutism | ||||
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