SOME TOXICOLOGICAL STUDIES ON CROTON OIL IN WHITE RATS | ||||
| Veterinary Medical Journal (Giza) | ||||
| Volume 40, Issue 2, April 1992, Page 135-143 PDF (2.55 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/vmjg.1992.372257 | ||||
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| Authors | ||||
| H BAKRY* 1; H El-MANSOURY2; A OSMAN* 3; R EL-SHAWARBY1 | ||||
| 1Fac Vet.Med. , Zagazig Univ. Banha branch | ||||
| 2Fac. Vet. Med. Cairo Univ. | ||||
| 3Dept. Theriogenology, Faculty of Veterinary Medicine, Assiut University, Assiut, Egypt | ||||
| Abstract | ||||
| Eighty albino rats of both sexs were used in this study and divided into 4 equal gorups. The first 3 groups were injected with croton oil in a dose of 0.50 and 1.00 mg/k gm B.Wt. respectively while the 4th group kep: as control and injected 0.5 ml tween-80 I/p. Results revealed thar R.B.Cs. count, HB®% and PCV were decreased while W.B.Cs count were increased significantly. Differentual leucocylic count Were Significantly decrease in lymphocytes and significantly increease in neutrophils and monocytes while eosinophil was slightly increased but basophils was not affected. Levels of GOT, GPT and AP were significantly increased, while T.P., albumin and globulin were significantly decreased in serum of toxicated rats. Urea and creatinine were decreased but potassium was increased in camparison to control group. Calcium and phosphorous levels were slightly changes in serum of treated rats. Microscopically the liver was congested with mononuclear aggregation and the hepatocyte suffered from dgenerative changes. The kidney showed haemorrahages with haemosidrosis, mononculear cell. | ||||
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