FOURNIER'S GANGRENE: CLINICAL, BIOCHEMICAL, BACTERIOLOGIC, IMMUNOLOGIC STUDY AND TREATMENT OUTCOME
El Awady, S., Khafagy, W., Fareed, M., Abd El-Raof, M., Ragab, E. (2007). FOURNIER'S GANGRENE: CLINICAL, BIOCHEMICAL, BACTERIOLOGIC, IMMUNOLOGIC STUDY AND TREATMENT OUTCOME. EKB Journal Management System, 26(2), 63-69. doi: 10.21608/ejsur.2007.372320
Saleh El Awady; Wael Khafagy; Mohamed Fareed; Mohamed Abd El-Raof; Elham Ragab. "FOURNIER'S GANGRENE: CLINICAL, BIOCHEMICAL, BACTERIOLOGIC, IMMUNOLOGIC STUDY AND TREATMENT OUTCOME". EKB Journal Management System, 26, 2, 2007, 63-69. doi: 10.21608/ejsur.2007.372320
El Awady, S., Khafagy, W., Fareed, M., Abd El-Raof, M., Ragab, E. (2007). 'FOURNIER'S GANGRENE: CLINICAL, BIOCHEMICAL, BACTERIOLOGIC, IMMUNOLOGIC STUDY AND TREATMENT OUTCOME', EKB Journal Management System, 26(2), pp. 63-69. doi: 10.21608/ejsur.2007.372320
El Awady, S., Khafagy, W., Fareed, M., Abd El-Raof, M., Ragab, E. FOURNIER'S GANGRENE: CLINICAL, BIOCHEMICAL, BACTERIOLOGIC, IMMUNOLOGIC STUDY AND TREATMENT OUTCOME. EKB Journal Management System, 2007; 26(2): 63-69. doi: 10.21608/ejsur.2007.372320

FOURNIER'S GANGRENE: CLINICAL, BIOCHEMICAL, BACTERIOLOGIC, IMMUNOLOGIC STUDY AND TREATMENT OUTCOME

The Egyptian Journal of Surgery
Volume 26, Issue 2, April 2007, Page 63-69  XML PDF (224.99 K)
Document Type: Original Article
DOI: 10.21608/ejsur.2007.372320
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Authors
Saleh El Awady* 1; Wael Khafagy1; Mohamed Fareed1; Mohamed Abd El-Raof2; Elham Ragab3
1Surgery, Mansoura University Hospital, Egypt
2Mansoura General Hospital
3Clinical Pathology, Mansoura University Hospital, Egypt
Abstract
Aim: Identify Fournier’s disease associations, outcome and survival factors. 
Methods: Fournier’s gangrene patients (34) were treated between 2003 to 2006. Data were collected about medical history, physical findings, metabolic tests, bacteriologic typing, immunologic screening for T cell function, serum IL-2, ICAM-I and γIFN with their management. 
Results: The disease had age range 3 – 67 years, polymicrobial nature, and low serum albumin (3.3 ± 0.6 mg/dl). Inadequate Tcell function (18255.3 ± 1641 CPM) and high ICAM-I, IL-2, γIFN (10.5 ± 0.7, 93.3 ± 1.6, 131 ± 2 pg/ml) were detected in Fournier’s disease but serum IL-2 was relevant to outcome (P = 0.0001). The survival factors were patients’ age (P = 0.0001), presentation timing (P = 0.001), both disease extent (P = 0.0001),septic shock(P = 0.01),severe SIRS (P = 0.001), serum albumin(P = 0.0001) and IL-2. 
Conclusion: Fournier’s disease is consistent with deviated metabolic status and immunologic dissonance, inciting local 
gangrenous process, these parameters are significant for disease outcome.  
Keywords
Necrotizing fasciitis; immunologic dissonance; SIRS
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