EFFECT OF HELICOBACTER PYLORI ERADICATION ON ULCER HEALING AND RECURRENCE AFTER SIMPLE CLOSURE OF PERFORATED DUODENAL ULCER
El-Nakeeb, A., Fikry, A., Mitwally, T., Fouda, E., El-Awadi, S., Abd El-Menem, H., Ghazy, H., Farid, M., Sherief, D. (2007). EFFECT OF HELICOBACTER PYLORI ERADICATION ON ULCER HEALING AND RECURRENCE AFTER SIMPLE CLOSURE OF PERFORATED DUODENAL ULCER. EKB Journal Management System, 26(2), 75-80. doi: 10.21608/ejsur.2007.372322
Ayman El-Nakeeb; Amir Fikry; Tito Mitwally; ELYamani Fouda; Saleh El-Awadi; Hisham Abd El-Menem; Hosam Ghazy; Mohamed Farid; Doaa Sherief. "EFFECT OF HELICOBACTER PYLORI ERADICATION ON ULCER HEALING AND RECURRENCE AFTER SIMPLE CLOSURE OF PERFORATED DUODENAL ULCER". EKB Journal Management System, 26, 2, 2007, 75-80. doi: 10.21608/ejsur.2007.372322
El-Nakeeb, A., Fikry, A., Mitwally, T., Fouda, E., El-Awadi, S., Abd El-Menem, H., Ghazy, H., Farid, M., Sherief, D. (2007). 'EFFECT OF HELICOBACTER PYLORI ERADICATION ON ULCER HEALING AND RECURRENCE AFTER SIMPLE CLOSURE OF PERFORATED DUODENAL ULCER', EKB Journal Management System, 26(2), pp. 75-80. doi: 10.21608/ejsur.2007.372322
El-Nakeeb, A., Fikry, A., Mitwally, T., Fouda, E., El-Awadi, S., Abd El-Menem, H., Ghazy, H., Farid, M., Sherief, D. EFFECT OF HELICOBACTER PYLORI ERADICATION ON ULCER HEALING AND RECURRENCE AFTER SIMPLE CLOSURE OF PERFORATED DUODENAL ULCER. EKB Journal Management System, 2007; 26(2): 75-80. doi: 10.21608/ejsur.2007.372322

EFFECT OF HELICOBACTER PYLORI ERADICATION ON ULCER HEALING AND RECURRENCE AFTER SIMPLE CLOSURE OF PERFORATED DUODENAL ULCER

The Egyptian Journal of Surgery
Volume 26, Issue 2, April 2007, Pages 75-80    PDF (283.34 K)
Document Type: Original Article
DOI: 10.21608/ejsur.2007.372322
Authors
Ayman El-Nakeeb* 1; Amir Fikry1; Tito Mitwally1; ELYamani Fouda1; Saleh El-Awadi1; Hisham Abd El-Menem1; Hosam Ghazy1; Mohamed Farid1; Doaa Sherief2
1Departments of General surgery, Mansoura University Hospital, Egypt
2Microbiology, Mansoura University Hospital, Egypt
Abstract
Aim: Helicobacter pylori (H.Pylori) plays a fundamental role in the causation of duodenal ulcer. This study was conducted to elucidate the prevalence of H.Pylori in patients with a perforated duodenal ulcer and to determine whether eradication of H.Pylori prevent ulcer recurrence following simple repair of the perforation. 
Methods: Eighty three patients admitted with perforated duodenal ulcer, only seventy seven patients treated with simple 
closure included in our study. Sixty five patients (84.4 %) who had H.Pylori infection were randomly divided into triple 
therapy group (34 patients) and alone group (31 patients). Follow up endoscopy was performed at 8 w, 16 w and 1 year to show the ulcer healing and determine H.Pylori. 
Results: The eradication of H.Pylori was significantly higher in triple therapy group than omeprazole alone group (at 8 weeks 91.2% vs. 22.6% respectively). Initial healing of ulcer was significantly better in eradication group and after one year the difference in ulcer recurrence between the two groups was statistically significant (2 (6.1%) in eradication group vs. 8 (29.6%) in omeprazole alone group P=0.001). 
Conclusion: H.Pylori was present at a high ratio in patients with duodenal ulcer perforation. Eradication of H.Pylori after 
simple closure of a perforated duodenal ulcer reduces the incidence of recurrent ulcer.
Keywords
Endoscopic examination; antral biopsies; triple therapy
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