EFFECT OF HELICOBACTER PYLORI ERADICATION ON ULCER HEALING AND RECURRENCE AFTER SIMPLE CLOSURE OF PERFORATED DUODENAL ULCER | ||||
The Egyptian Journal of Surgery | ||||
Volume 26, Issue 2, April 2007, Page 75-80 PDF (283.34 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejsur.2007.372322 | ||||
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Authors | ||||
Ayman El-Nakeeb* 1; Amir Fikry![]() | ||||
1Departments of General surgery, Mansoura University Hospital, Egypt | ||||
2Microbiology, Mansoura University Hospital, Egypt | ||||
Abstract | ||||
Aim: Helicobacter pylori (H.Pylori) plays a fundamental role in the causation of duodenal ulcer. This study was conducted to elucidate the prevalence of H.Pylori in patients with a perforated duodenal ulcer and to determine whether eradication of H.Pylori prevent ulcer recurrence following simple repair of the perforation. Methods: Eighty three patients admitted with perforated duodenal ulcer, only seventy seven patients treated with simple closure included in our study. Sixty five patients (84.4 %) who had H.Pylori infection were randomly divided into triple therapy group (34 patients) and alone group (31 patients). Follow up endoscopy was performed at 8 w, 16 w and 1 year to show the ulcer healing and determine H.Pylori. Results: The eradication of H.Pylori was significantly higher in triple therapy group than omeprazole alone group (at 8 weeks 91.2% vs. 22.6% respectively). Initial healing of ulcer was significantly better in eradication group and after one year the difference in ulcer recurrence between the two groups was statistically significant (2 (6.1%) in eradication group vs. 8 (29.6%) in omeprazole alone group P=0.001). Conclusion: H.Pylori was present at a high ratio in patients with duodenal ulcer perforation. Eradication of H.Pylori after simple closure of a perforated duodenal ulcer reduces the incidence of recurrent ulcer. | ||||
Keywords | ||||
Endoscopic examination; antral biopsies; triple therapy | ||||
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