GROWTH DIFFERENTIATION FACTOR-8 EFFECT ON PROGESTERONE LEVELS DURING CONTROLLED OVARIAN STIMULATION IN INTRACYTOPLASMIC SPERM INJECTION | ||
ALEXMED ePosters | ||
Article 1, Volume 6, Issue 3, July 2024, Pages 36-37 | ||
Document Type: Preliminary preprint short reports of original research | ||
DOI: 10.21608/alexpo.2024.308695.1905 | ||
Authors | ||
Sherif Anis Hebisha1; Doaa Ibrahim Hashad2; Ahmed Shoukry Abdelmoneim Rageh3; Shaymaa Tarek Elsayed Abdelhameed* 4 | ||
1Department of Obstetrics and Gynecology, Faculty of Medicine, Alexandria University | ||
2Department of Clinical and Chemical pathology, Faculty of Medicine, Alexandria University | ||
3Department of Obstetrics and Gynecology, Alexandria Faculty of Medicine, Alexandria University | ||
4Department of Obstetrics and Gynecology, Faculty of medicine, Alexandria University | ||
Abstract | ||
Intracytoplasmic sperm injection includes ovarian stimulation to retrieve mature oocytes, fertilize them by sperms and then embryo transfer after endometrial preparation.GDF-8 is a growth factor belonging to the transforming growth factor- β (TGF-β) superfamily that found to be highly expressed in the female reproductive system in addition to its first discovered site of release from myocytes and showed to have a dynamic trend, regulatory role and negative correlation with progesterone serum levels during controlled ovarian stimulation (COS). Aim: The aim of this study was to investigate the role of GDF-8 in regulating progesterone levels during controlled ovarian stimulation in patients undergoing IVF-ICSI- ET and evaluate its effect on pregnancy rate. Patients and Methods: 42 women undergoing intracytoplasmic sperm injection are enrolled in a prospective cohort study. Patients are selected with the fulfillment of the inclusion criteria. GDF-8 and progesterone (P4) serum levels both were measured in this study at 3 different time points during COS, human chorionic gonadotropin (hCG) administration day, oocyte pick up (OPU) day and 14 days after embryo transfer. | ||
Keywords | ||
GROWTH DIFFERENTIATION FACTOR-8; PROGESTERONE; IN INTRACYTOPLASMIC SPERM INJECTION | ||
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