The challenges in combating multidrug-resistant Mycobacterium tuberculosis | ||||
| Journal of Medical and Life Science | ||||
| Volume 6, Issue 3, September 2024, Page 318-327 PDF (770.09 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jmals.2024.372569 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Furqan Majid Kadhum* 1; Zena Abdullah Khalaf 1; Suha A. Muneem2
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| 1Department of Optics Techniques, Al-Farabi University College, Baghdad, Iraq | ||||
| 2Department of Chemistry and Biochemistry, AL-Iraqia University College of Medicine | ||||
| Abstract | ||||
| The essential aim of the current investigation is to focus on how Mycobacterium TB, the bacteria that causes tuberculosis, becomes resistant to treatment. This review highlights the following crucial points: Introduction to the incidence of TB and its relevance as a worldwide health concern, particularly with the introduction of multidrug-resistant forms. Mycobacterium tuberculosis has various mechanisms that allow it to resist anti-TB medications. These include an impermeable cell wall, a slow metabolism, and the presence of drug excretion pumps. The transmission of the infection and the risk factors that increase the likelihood of developing tuberculosis are detailed. An in-depth examination into how molecules develop resistance to some of the most used TB medications, such as isoniazid, rifampicin, pyrazinamide, ethambutol, fluoroquinolones, and aminoglycosides, as well as genetic alterations associated with resistance. Discuss the need to use more than one medicine to treat tuberculosis so that resistance does not develop. This refers to the present tendency in research to discover novel compounds capable of killing drug-resistant strains. In summary, this review covers molecular and cellular drug resistance mechanisms in M. tuberculosis, focusing on the most important tuberculosis drugs and novel treatment methods. | ||||
| Keywords | ||||
| Mycobacterium tuberculosis; multidrug-resistant; tuberculosis; anti-TB medications | ||||
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