Evaluation of Ocular In-Situ Hydro-gel Formulated prednisolone for Controlling Experimentally Induced Uveitis In Rabbits
Elshazly, A., El-Hossary, G., Abdel-Ghaffar, A., Mahmoud, A., Moemen, L., Elfoly, M., Elgohary, A., Ata, A. (2024). Evaluation of Ocular In-Situ Hydro-gel Formulated prednisolone for Controlling Experimentally Induced Uveitis In Rabbits. EKB Journal Management System, (), 1-14. doi: 10.21608/ejvs.2024.293173.2125
Amany H.M. Elshazly; Ghada Ghanem El-Hossary; Amany Abdel-Ghaffar; Atef Mohamed Mahmoud; Leqaa Moemen; Marwa Elfoly; Amal Elgohary; Ahmed Mostafa Ata. "Evaluation of Ocular In-Situ Hydro-gel Formulated prednisolone for Controlling Experimentally Induced Uveitis In Rabbits". EKB Journal Management System, , , 2024, 1-14. doi: 10.21608/ejvs.2024.293173.2125
Elshazly, A., El-Hossary, G., Abdel-Ghaffar, A., Mahmoud, A., Moemen, L., Elfoly, M., Elgohary, A., Ata, A. (2024). 'Evaluation of Ocular In-Situ Hydro-gel Formulated prednisolone for Controlling Experimentally Induced Uveitis In Rabbits', EKB Journal Management System, (), pp. 1-14. doi: 10.21608/ejvs.2024.293173.2125
Elshazly, A., El-Hossary, G., Abdel-Ghaffar, A., Mahmoud, A., Moemen, L., Elfoly, M., Elgohary, A., Ata, A. Evaluation of Ocular In-Situ Hydro-gel Formulated prednisolone for Controlling Experimentally Induced Uveitis In Rabbits. EKB Journal Management System, 2024; (): 1-14. doi: 10.21608/ejvs.2024.293173.2125

Evaluation of Ocular In-Situ Hydro-gel Formulated prednisolone for Controlling Experimentally Induced Uveitis In Rabbits

Egyptian Journal of Veterinary Sciences
Articles in Press, Corrected Proof, Available Online from 08 August 2024  XML PDF (1.56 MB)
Document Type: Original Article
DOI: 10.21608/ejvs.2024.293173.2125
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Authors
Amany H.M. Elshazly email 1; Ghada Ghanem El-Hossary1; Amany Abdel-Ghaffar2; Atef Mohamed Mahmoud2; Leqaa Moemen2; Marwa Elfoly3; Amal Elgohary4; Ahmed Mostafa Ata email orcid 2
1Pharmacology Department, Research Institute of Ophthalmology, Giza, Egypt.
2Biochemistry Department, Research Institute of Ophthalmology, Giza, Egypt.
3Ophthalmology Department, Research Institute of Ophthalmology, Giza, Egypt.
4Ocular Physiology Department. Research Institute of Ophthalmology, Giza, Egypt.
Abstract
One of the major limitations in ophthalmic delivery is the poor bioavailability of drugs from conventional eye drops. Pre-corneal drug loss factors include rapid tear turnover, transient residence time, and the relative impermeability of corneal epithelium. Occasionally, systemic absorption of drugs may result in systemic side effects.
To overcome these issues, controlled drug delivery systems were developed, including different types of in situ gel-forming systems based on different mechanisms (temperature, pH, or ion activated) using different polymers that have been explored for sustained ocular delivery. This study aims to formulate ocular drugs as loaded ionic and pH-activated in situ hydrogel formulas for controlled drug delivery systems aiming to increase the pre-corneal residence time and reduce the frequency of application, limit side effects, and improve patient adherence to therapy. This study will conduct biochemical and ophthalmological tests for combined lecithin, alginic acid, and chitosan-loaded prednisolone eye drops in an animal model of induced uveitis.
Keywords
lecithin; chitosan; alginic acid; eye drops; uveitis
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