EVOLUTION OF COLORECTAL CANCER IN SCHISTOSOMIASIS
Farid, M., El- Awady, S., Abdel-Moneim, H., Sakr, H., Abd El-Ghafar, A., El- Desouky, E. (2006). EVOLUTION OF COLORECTAL CANCER IN SCHISTOSOMIASIS. EKB Journal Management System, 25(4), 206-212. doi: 10.21608/ejsur.2006.372983
Mohamed Farid; Saleh El- Awady; Hesham Abdel-Moneim; Hanem Sakr; Adel Abd El-Ghafar; Ebrahim El- Desouky. "EVOLUTION OF COLORECTAL CANCER IN SCHISTOSOMIASIS". EKB Journal Management System, 25, 4, 2006, 206-212. doi: 10.21608/ejsur.2006.372983
Farid, M., El- Awady, S., Abdel-Moneim, H., Sakr, H., Abd El-Ghafar, A., El- Desouky, E. (2006). 'EVOLUTION OF COLORECTAL CANCER IN SCHISTOSOMIASIS', EKB Journal Management System, 25(4), pp. 206-212. doi: 10.21608/ejsur.2006.372983
Farid, M., El- Awady, S., Abdel-Moneim, H., Sakr, H., Abd El-Ghafar, A., El- Desouky, E. EVOLUTION OF COLORECTAL CANCER IN SCHISTOSOMIASIS. EKB Journal Management System, 2006; 25(4): 206-212. doi: 10.21608/ejsur.2006.372983

EVOLUTION OF COLORECTAL CANCER IN SCHISTOSOMIASIS

The Egyptian Journal of Surgery
Volume 25, Issue 4, October 2006, Page 206-212  XML PDF (505.64 K)
Document Type: Original Article
DOI: 10.21608/ejsur.2006.372983
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Authors
Mohamed Farid1; Saleh El- Awady1; Hesham Abdel-Moneim* 1; Hanem Sakr2; Adel Abd El-Ghafar3; Ebrahim El- Desouky4
1Colorectal Surgery Unit, Mansoura Faculty of Medicine, Egypt.
2Radiotherapy and nuclear medicine department, Mansoura Faculty of Medicine, Egypt.
3Community medicine department, Mansoura Faculty of Medicine, Egypt
4Pathology department, Mansoura Faculty of Medicine, Egypt.
Abstract
Aim: To define the clinico-pathologic character of schistosomiasis mansoni associated colorectal cancer (S.CRC) and the 
possible carcinogenic relation of Schistosoma mansoni (S.M). 
Methods: This study included 176 patients with colorectal cancer associated with S.M. Their clinical database and surgical pathology sheets were documented with the detection of S.M on stool analysis, serologic tests, pathologic associated lesions and tumor P53 protein expression using immuno-cytochemical assay. 
Results: Sixty eight patients (40%) with S.CRC were below 40 years with male predominance (1.8 – 1), distal CRC 
predominance in 109 patients (62%), mucinous type in 58 patients (33%), higher grades II, III in 136 patients (79%), with 
significant angio-invasion in 50 patients (30%), lymph vessels invasion in 50 patients (35%) and perineural invasion in 17 
patients (10%), associates with poor immune response in 8 patients (5%), preceded with schistosomal lesions especially in patients with schistosomal colitis ≥ 10 years, associates with TP53 in 114 cases (65%) and presented at advanced stages in 99 cases (56%) with only hepatic metastasis in 28 cases (90%). 
Conclusion: S.CRC is a special clinical entity that has an aggressive pathologic pattern, bad biologic behavior and the SM is implicated in SCRC progression.
Keywords
Bilharzial associated colorectal cancer; parasitic colitis
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