ROLE OF OCTREOTIDE IN CONTROL OF LYMPHORRHEA AFTER AXILLARY NODE DISSECTION IN MASTECTOMY OPERATIONS - A RANDOMIZED CONTROLLED STUDY | ||||
| The Egyptian Journal of Surgery | ||||
| Volume 25, Issue 1, January 2006, Page 15-19 PDF (166.16 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejsur.2006.373097 | ||||
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| Authors | ||||
| Sabry Mahmoud* ; Saleh El-Awady; Kamal Abdel-Elah; Abdel-Hamid Eldesoky | ||||
| General Surgery Department, Faculty of Medicine, Mansoura University-Egypt | ||||
| Abstract | ||||
| Aim: Lymphorrhea and seroma formation are disabling and serious complications of axillary lymphadenectomy. The role of octreotide in control of post axillary dissection lymphorrhea will be assessed in this study. Methods: Fifty female patients with cancer breast of different stages were subjected for modified radical mastectomy and divided into two groups; the first group was given octreotide (Sandostatin, Novartis Pharma AG, Basle, Switzerland) 0.1 mg subcutaneous / 8 hours for 7 days, the other group was the control group. Both groups were evaluated for amount and duration of lymphorrhea as well as infection and hematoma formation. Results: A significant difference in the amount and duration of lymphorrhea between the two groups was observed (P = 0.0003). In the first 8 days, the mean amount of lymphorrhea was 145.0 ± 45.8 cc per day and mean duration of drainage was 27.0 ± 7.59 days in control group. In the treatment group, the mean amount of lymphorrhea was 104.0 ± 29 cc per day and the mean duration of drainage was 12.7 ± 6.74 days. Conclusion: Octreotide could be used successfully for control of post-axillary lymphadenectomy lymphorrhea and this may lower the incidence of lymphedema and lymphosarcoma | ||||
| Keywords | ||||
| Somatostatin; post mastectomy seroma; axillary lymphadenectomy | ||||
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