Synthesis, Characterization, Antimicrobial Assessments, Potential Antioxidant And Molecular Docking Studies Of Polyfunctional Substituted Azoles, Azines, And Their Analogs Linked Sulfamethoxazole Moiety
mousa, I., El-Maghraby, A., Hassane, A., Gaafar, H., Yahya, M., Hussein, A. (2025). Synthesis, Characterization, Antimicrobial Assessments, Potential Antioxidant And Molecular Docking Studies Of Polyfunctional Substituted Azoles, Azines, And Their Analogs Linked Sulfamethoxazole Moiety. EKB Journal Management System, 68(3), 329-344. doi: 10.21608/ejchem.2024.286549.9673
ibrahim abdel-motaleb mousa; Awatef M. El-Maghraby; Abdallah M. A. Hassane; Hatem Gaafar; Muhammad E. Yahya; Abdelhaleem M Hussein. "Synthesis, Characterization, Antimicrobial Assessments, Potential Antioxidant And Molecular Docking Studies Of Polyfunctional Substituted Azoles, Azines, And Their Analogs Linked Sulfamethoxazole Moiety". EKB Journal Management System, 68, 3, 2025, 329-344. doi: 10.21608/ejchem.2024.286549.9673
mousa, I., El-Maghraby, A., Hassane, A., Gaafar, H., Yahya, M., Hussein, A. (2025). 'Synthesis, Characterization, Antimicrobial Assessments, Potential Antioxidant And Molecular Docking Studies Of Polyfunctional Substituted Azoles, Azines, And Their Analogs Linked Sulfamethoxazole Moiety', EKB Journal Management System, 68(3), pp. 329-344. doi: 10.21608/ejchem.2024.286549.9673
mousa, I., El-Maghraby, A., Hassane, A., Gaafar, H., Yahya, M., Hussein, A. Synthesis, Characterization, Antimicrobial Assessments, Potential Antioxidant And Molecular Docking Studies Of Polyfunctional Substituted Azoles, Azines, And Their Analogs Linked Sulfamethoxazole Moiety. EKB Journal Management System, 2025; 68(3): 329-344. doi: 10.21608/ejchem.2024.286549.9673

Synthesis, Characterization, Antimicrobial Assessments, Potential Antioxidant And Molecular Docking Studies Of Polyfunctional Substituted Azoles, Azines, And Their Analogs Linked Sulfamethoxazole Moiety

Egyptian Journal of Chemistry
Volume 68, Issue 3, March 2025, Page 329-344  XML PDF (1.45 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.286549.9673
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Authors
ibrahim abdel-motaleb mousa1; Awatef M. El-Maghraby2; Abdallah M. A. Hassane3; Hatem Gaafar4; Muhammad E. Yahya email orcid 5; Abdelhaleem M Hussein6
1Chemistry department-Faculty of science- South valley university- Qena - Egypt
2Chemistry Department, Faculty of Science, South Valley University, Qena 83523, Egypt
3Botany and Microbiology Department, Faculty of Science, Al-Azhar University, Assiut
4national research center/EGYPT
5Department of chemistry, faculty of science, south valley university
6Department of Chemistry, Faculty of Science, Al Azhar University, Assiut 71524, Egypt
Abstract
A new series of substituted azoles, azines, and their analogs linked sulfamethoxazole moiety was designed and synthesized. The antioxidant activity study of our synthesized compounds and molecular docking enhancement were achieved. Moreover, the antimicrobial assay indicated that compound 1 is the more active compound against all the stains compared to the reference drugs. So, reactions of β-oxobutanamide derivative 1 with different reagents afforded compounds 2a,b, 5, 7 and 8 12 and 14. Coupling of 1 with diazonium salt yield aryl hydrazones 10a,b which reacts with ethyl chloroformate to yield the triazinediones 11a,b. Reactions of enaminone 12 with some electrophilic and nucleophilic reagents to yield compounds 16, 21, 22, 23, 24 and 25 respectively. The structures of all compounds were characterized by means of spectral and elemental analyses.
Keywords
Azoles; azines; antioxidants; antibacterial agents; molecular docking
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