THERAPEUTIC AND IMMUNOMODULATORY EFFECTS OF ACACIA NILOTICA ON EXPERIMENTALLY TRICHINELLA SPIRALIS INFECTED MICE
SHALAAN, F., AMMAR, A., ABD-ELHAFIZ, H., ABDEL RAOUF, S., BADR, N., AL-ATTAR, T. (2024). THERAPEUTIC AND IMMUNOMODULATORY EFFECTS OF ACACIA NILOTICA ON EXPERIMENTALLY TRICHINELLA SPIRALIS INFECTED MICE. EKB Journal Management System, 54(2), 187-196. doi: 10.21608/jesp.2024.373517
FATMA H. SHALAAN; AMANY I. AMMAR; HUDA IBRAHIM ABD-ELHAFIZ; SHAIMAA Y. ABDEL RAOUF; NAHLA MUSTAFA BADR; TAHANY A. A. AL-ATTAR. "THERAPEUTIC AND IMMUNOMODULATORY EFFECTS OF ACACIA NILOTICA ON EXPERIMENTALLY TRICHINELLA SPIRALIS INFECTED MICE". EKB Journal Management System, 54, 2, 2024, 187-196. doi: 10.21608/jesp.2024.373517
SHALAAN, F., AMMAR, A., ABD-ELHAFIZ, H., ABDEL RAOUF, S., BADR, N., AL-ATTAR, T. (2024). 'THERAPEUTIC AND IMMUNOMODULATORY EFFECTS OF ACACIA NILOTICA ON EXPERIMENTALLY TRICHINELLA SPIRALIS INFECTED MICE', EKB Journal Management System, 54(2), pp. 187-196. doi: 10.21608/jesp.2024.373517
SHALAAN, F., AMMAR, A., ABD-ELHAFIZ, H., ABDEL RAOUF, S., BADR, N., AL-ATTAR, T. THERAPEUTIC AND IMMUNOMODULATORY EFFECTS OF ACACIA NILOTICA ON EXPERIMENTALLY TRICHINELLA SPIRALIS INFECTED MICE. EKB Journal Management System, 2024; 54(2): 187-196. doi: 10.21608/jesp.2024.373517

THERAPEUTIC AND IMMUNOMODULATORY EFFECTS OF ACACIA NILOTICA ON EXPERIMENTALLY TRICHINELLA SPIRALIS INFECTED MICE

Journal of the Egyptian Society of Parasitology
Article 3, Volume 54, Issue 2, August 2024, Page 187-196  XML PDF (680.64 K)
Document Type: Original Article
DOI: 10.21608/jesp.2024.373517
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Authors
FATMA H. SHALAAN1; AMANY I. AMMAR1; HUDA IBRAHIM ABD-ELHAFIZ2; SHAIMAA Y. ABDEL RAOUF3; NAHLA MUSTAFA BADR4; TAHANY A. A. AL-ATTAR1
1Department of Parasitology, Faculty of Medicine, Menoufia University, Egypt
2Department of Pharmacology, Faculty of Medicine, Menoufia University, Egypt
3Department of Public Health and Community Medicine
4Department of Pathology, Faculty of Medicine, Menoufia University, Egypt
Abstract
Trichinosis is a common infection that spreads primarily through food. None of the therapies,
including albendazole (ALZ), have significant effectiveness against Trichinella spiralis larvae
encapsulated in muscle, so there is a need to find new, effective trichinosis medications. Acacia
nilotica (A. nilotica) is linked to many biological activities as anti-inflammatory, anti-microbial
and anti-carcinogenic activities. This study determined the efficacy of A. nilotica alone or in
combination with ALZ for treating intestinal and muscular trichinosis.
In this study, fifty mice were divided into five groups, non-infected control group, T. spiralis
infected control group, A. nilotica-treated group, ALZ treated group and finally Acacia-ALZ
treated group. Adult count, larval load, intestinal and muscular histology, COX2 expression, and
measurement of CD4+ & CD8+ lymphocytes percentages were investigated.
The results showed that mice received the combined therapy achieved the greatest outcomes in
terms of the criteria employed. ALZ was better than Acacia for intestinal trichinosis, although
Acacia was better for muscular trichinosis.
Keywords
Trichinella spiralis, Acacia nilotica, Albendazole; CD4+; CD8+; COX2
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