Roles of PPARα and HNF4α within the emergence of fatty liver disease pathophysiology
rafat, A., hegab, D., Abdel-Aziz, H., Hassan, A., Ahmed, H. (2024). Roles of PPARα and HNF4α within the emergence of fatty liver disease pathophysiology. EKB Journal Management System, 28(3.), 27-34. doi: 10.21608/smj.2024.302777.1485
asmaa rafat; dina monir hegab; Hekmet O Abdel-Aziz; Asmaa Hassan; Hoda Mostafa Ahmed. "Roles of PPARα and HNF4α within the emergence of fatty liver disease pathophysiology". EKB Journal Management System, 28, 3., 2024, 27-34. doi: 10.21608/smj.2024.302777.1485
rafat, A., hegab, D., Abdel-Aziz, H., Hassan, A., Ahmed, H. (2024). 'Roles of PPARα and HNF4α within the emergence of fatty liver disease pathophysiology', EKB Journal Management System, 28(3.), pp. 27-34. doi: 10.21608/smj.2024.302777.1485
rafat, A., hegab, D., Abdel-Aziz, H., Hassan, A., Ahmed, H. Roles of PPARα and HNF4α within the emergence of fatty liver disease pathophysiology. EKB Journal Management System, 2024; 28(3.): 27-34. doi: 10.21608/smj.2024.302777.1485

Roles of PPARα and HNF4α within the emergence of fatty liver disease pathophysiology

Sohag Medical Journal
Volume 28, Issue 3., 2024, Page 27-34  XML PDF (1.27 MB)
Document Type: Review Article
DOI: 10.21608/smj.2024.302777.1485
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Authors
asmaa rafat email 1; dina monir hegaborcid 2; Hekmet O Abdel-Aziz3; Asmaa Hassan4; Hoda Mostafa Ahmed5
1physiology department faculty of medicine sohag university
2Medical Physiology department, Sohag Faculty of Medicine, Sohag university
3Department, of Histology, Facultyof Medicine, Sohag University.
4lecturer in physiology department, Faculty of Medicine, Sohag university
5Department of Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt.
Abstract
Globally, non-alcoholic fatty liver disease (NAFLD) is one of the most prevalent forms of persistent liver disease. It is regarded as a constituent of metabolic disease, which additionally comprises diabetes, overweight, resistance to insulin, hypertension, and dyslipidemia. The most common reason for NAFLD is disturbed whole-body energy balance brought on by consuming more calories than burning them. The extra energy is subsequently deposited in an aberrant fat stores. Alterations to the hepatic metabolic system are the hallmark of this disease. The characteristic feature underlying NAFLD is liver lipid accumulation in deficient excessive alcohol intake. PPARα is ligand-induced synthesis molecules that regulate the transcription of several processes primarily expressed in hepatic tissue, where it is involved in the fatty acid oxidation, regulation of many pathways implicated in metabolism, and regulates the energy and lipid balance. HNF4α is a multi-gene master regulator, that are involved in gluconeogenesis, and lipid homeostasis. Liver HNF4α not only controls VLDL secretion but also has a crucial influence in controlling liver lipolysis.
Keywords
metabolic disease; excess calories; overweight; mechanisms
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