PERI-OPERATIVE EFFECTS OF ROFECOXIB (SELECTIVE CYCLOOXYGENASE-2-INHIBITOR) ON COLONIC ANASTOMOSIS IN RATS | ||||
| The Egyptian Journal of Surgery | ||||
| Volume 23, Issue 1, January 2004, Page 30-37 PDF (543.29 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejsur.2004.374034 | ||||
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| Authors | ||||
| A. Moatamed* 1; M.R. Abdelsamad2; S.E. Zaid3 | ||||
| 1Departments of General Surgery, Mansoura University, Egypt | ||||
| 2Histology and Cytology, Mansoura University, Egypt | ||||
| 3Clinical Pharmacology, Faculty of Medicine, Mansoura University, Egypt | ||||
| Abstract | ||||
| Rofecoxib (selective cyclo-oxygenase-2-inhibitor) had a wide range of surgical therapies especially (analgesic) in the peri-operative period. Its effects on the intestinal wound healing is unknown. The aim of the studied was to investigate effects of Rofecoxib on colonic anastomosis in rats in the first post-operative week. The study included 40 male rats divided into two groups, studied, 20 and control 20. In both, resection-anastomosis of left colon with interrupted single layer of vicryl 6/0 was done. The control group received distilled water and the studied group received Rofecoxib pre-operatively and during the first post-operative week. Bursting pressure of the anastomosis in the studied group decreased from 116.40 + 10.20mmHg preoperatively to 41.60 + 3.00 mmHg and 49.40 + 5.79 mmHg respectively at 3 and 7 days post-operatively (P<0.001) compared to 124.05 + 11.15 mmHg, 107.70 + 12.90 mmHg and 114.55 + 12.91 mmHg respectively in the control group at the same intervals. Epithelialization of grade I with numerous inflammatory cells was noted in the anastomosis in the studied group at the third post-operative day, while epithelialization of grade III and less numerous inflammatory cells together with reformed lamina propria and congested blood vessels were noted at the seventh post-operative day. Incidence of colonic of fistula was 33% in the studied group versus 9% in the control group at the seventh post-operative day. While mortality was 25% in the studied group compared to 9% in the control group at the seventh post-operative day. No fistula or mortality occurred on the third post-operative day. In conclusion, administration of Rofecoxib significantly impaired healing (decreased cellular proliferation and collagen deposition) and decreased bursting pressure of colonic anastomosis in rats during the first post-operative week. Rofecoxib increased incidence of fistula in this period. | ||||
| Keywords | ||||
| Peri; operative effects; Rofecoxib; colonic anastomosis; rats | ||||
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