Exploring the Metabolic Symphony of Fungal-Bacterial Coculturing and Individual Cultures as antimicrobial | ||||
| Journal of Basic and Environmental Sciences | ||||
| Volume 11, Issue 2, April 2024, Page 208-218 PDF (918.59 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/jbes.2024.375049 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Mervat G. Hassan1; Ahmed I. Sharra1; Mohamed E. Elawady2; Ahmed A. Hamed2; Mahmoud A. Amer3 | ||||
| 1Microbiology Department, Faculty of Science, Benha University, Benha, Egypt | ||||
| 2Microbial Biotechnology Department, National Research Centre, El- Buhouth Street, Dokki, Cairo, Egypt. | ||||
| 3Microbial Chemistry Department, National Research Centre, El-Buhouth Street, Dokki, Cairo, Egypt. | ||||
| Abstract | ||||
| This research delves into the dynamic alterations in antimicrobial activity resulting from the co-cultivation of a fungus and an actinomycete, with a keen focus on discerning the nuanced changes influenced by their interplay. The initiation of the study involved a meticulous isolation process targeting both fungi and actinomycetes from marine samples, specifically Sea water from Hurghada, Ras Sedr sediments, and Ain Sokhna sediment. The isolated microorganisms, coded as the fungus FGH2 and the actinomycete AGH5, were subjected to individual and co-culture conditions. A detailed exploration into the metabolites produced by these microorganisms ensued, involving the preparation of crude extracts from both individual cultures and their co-culture scenarios. Notably, the findings strongly suggest the existence of synergistic effects within the co-culture, influencing the biosynthesis of unique compounds. The varied biological activities associated with these compounds further underscore the potential of the co-cultivation strategy in eliciting novel and enhanced antimicrobial properties.This study, anchored in a thorough investigation of individual and co-cultured microbial metabolites, provides a nuanced understanding of the intricate dynamics shaping antimicrobial activities. The insights gained pave the way for future research exploring the applications of these synergistic interactions in drug discovery and biotechnological advancements. | ||||
| Keywords | ||||
| Fungi; Bacteria; Coculturing; secondary metabolites | ||||
|
Statistics Article View: 77 PDF Download: 84 |
||||
