Impact of Advanced Metabonomic Technologies on Surgical Interventions: A Comprehensive Review

Alonazi, Abdullah Sabbar Awad; Aiyas, Hassan Mouse Yahya; Alharbi, Metab Moammed Marsil; Alanazi, Abdullah Mdibgh Fadhil; Al-Masoudi, Adel Mohammed; Al-Harbi, Muhammad Hamoud; Alotaibi, Faisal Farraj; Alabdullah, Abdulelah Hamad

doi:10.21608/ejchem.2024.303723.9999

	Impact of Advanced Metabonomic Technologies on Surgical Interventions: A Comprehensive Review
Egyptian Journal of Chemistry
Volume 67, Issue 13, December 2024, Pages 743-758 PDF (504.63 K)
Document Type: Review Articles
DOI: 10.21608/ejchem.2024.303723.9999
Authors
Abdullah Sabbar Awad Alonazi¹; Hassan Mouse Yahya Aiyas¹; Metab Moammed Marsil Alharbi¹; Abdullah Mdibgh Fadhil Alanazi²; Adel Mohammed Al-Masoudi³; Muhammad Hamoud Al-Harbi⁴; Faisal Farraj Alotaibi⁵; Abdulelah Hamad Alabdullah⁶
¹Operation Rooms Technician, Northern Area Armed Forces Hospital, Kingdom of Saudi Arabia
²Technician-Phlebotomy, Northern Armed Forces Hospital, Kingdom of Saudi Arabia
³Technician Operation Rooms, Sabya General Hospital, Saudi Arabia
⁴Emergency medical services specialist, Prince Sultan Military Medical City P.BOX. 7897 Riyadh 11159. Kingdom of Saudi Arabia
⁵Paramedic Specialist, Prince Sultan Military Medical City P.BOX. 7897 Riyadh 11159. Kingdom of Saudi Arabia,
⁶Pharmacy Technician, Prince Sultan Military Medical City P.BOX. 7897 Riyadh 11159. Kingdom of Saudi Arabia
Abstract
Aim: This study aims to evaluate the impact and potential of advanced metabonomic technologies in enhancing surgical decision-making and patient outcomes, focusing on oncological and critical care settings. Methods: A comprehensive review of literature was conducted to gather and analyze data on the application of MAS-NMR spectroscopy, mass spectrometry imaging (MSI), and rapid evaporative ionization mass spectrometry (REIMS) in surgical contexts. Studies encompassing tumor margin assessment, intraoperative tissue characterization, and metabolic profiling in critical illness were reviewed to synthesize current findings and technological advancements. Results: MAS-NMR spectroscopy demonstrated high sensitivity in distinguishing between benign and malignant tissues, offering rapid and accurate intraoperative guidance. MSI provided histologically specific molecular profiles, enhancing surgical precision in tumor resections. REIMS enabled real-time tissue analysis during surgery, facilitating immediate decision-making based on molecular composition. These technologies showed promise in predicting patient outcomes, optimizing therapeutic strategies, and minimizing surgical complications. Conclusion: Advanced metabonomic technologies represent a paradigm shift in surgical practice, offering precise, real-time molecular insights that improve diagnostic accuracy and therapeutic efficacy. Integration of MAS-NMR spectroscopy, MSI, and REIMS enhances surgical decision-making in oncology and critical care, paving the way for personalized treatment approaches and improved patient outcomes.
Keywords
MAS-NMR spectroscopy; mass spectrometry imaging; rapid evaporative ionization mass spectrometry; surgical oncology; critical care; metabonomics

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