Diagnostic Accuracy of Low-Cost Blood Test Inflammatory Markers in Severe Ulcerative Colitis

Mohammad Sadek, Ayman Magd Eldin; Yousef Salim, Abdulqadir Mohammed; Afify, Afify Fahmy; Ibrahim, Nevin Fouad; Salem, Sara Mohamed

doi:10.21608/zumj.2024.311594.3517

	Diagnostic Accuracy of Low-Cost Blood Test Inflammatory Markers in Severe Ulcerative Colitis
Zagazig University Medical Journal
Article 5, Volume 30, Issue 7, October 2024, Page 3211-3226 PDF (831.85 K)
Document Type: Original Article
DOI: 10.21608/zumj.2024.311594.3517
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Authors
Ayman Magd Eldin Mohammad Sadek ¹; Abdulqadir Mohammed Yousef Salim ²; Afify Fahmy Afify³; Nevin Fouad Ibrahim¹; Sara Mohamed Salem⁴
¹Associate Professor of Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt
²Internal Medicine Department, Faculty of Medicine, Tripoli University - Libya
³Professor of Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt
⁴Assistant Professor of Internal Medicine Department, Faculty of Medicine, Zagazig University, Egypt
Abstract
Background: Ulcerative colitis (UC) is a long-standing inflammatory disease with remission and exacerbation courses. Early detection of relapses, flares, disease activity changes, and treatment responses is key to optimizing patient management. The evidence about the usefulness of low-cost blood test inflammatory markers concerning UC disease activity is still limited. This study aimed to evaluate the diagnostic accuracy of low-cost serum inflammatory markers in monitoring UC activity. Methods: This cross-sectional study was conducted in the inflammatory bowel disease (IBD) clinic, Zagazig University Hospital, Egypt. Fecal calprotectin and low-cost serum inflammatory markers including C-reactive protein (CRP), C-reactive protein-albumin ratio (CAR), lymphocyte-monocyte ratio (LMR), mean platelets volume-lymphocyte ratio (MLR), mean platelets volume-platelets ratio (MPR), neutrophil-lymphocyte ratio (NLR), platelets-lymphocyte ratio (PLR), red cell distribution width-platelet ratio (RPR), and systemic immune-inflammation index (SII) were measured. Results: The area under the curve (AUC) of CRP, CAR, Fecal calprotectin, LMR, SII, and MPR in the diagnosis of severe UC were 0.85, 0.85, 0.84, 0.81, 0.83, and 0.80 respectively. CRP, CAR, Fecal calprotectin, NLR, LMR, SII, Albumin, MPR, and RPR were independent predictors for Mayo score grade 3. Conclusion: low-cost serum inflammatory markers such as CRP, CAR, LMR, SII, and MPR showed diagnostic accuracy in monitoring severe UC activity.
Keywords
Low-cost; Inflammatory Markers; Ulcerative Colitis


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