The study of Hemopexin concentration as a predictor for relapsing nephrotic syndrome in children | ||||
| Benha Medical Journal | ||||
| Article 5, Volume 42, Issue 1, January 2025, Page 45-55 PDF (1.03 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2024.295026.2092 | ||||
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| Authors | ||||
Wesam E Afifi1; Abd El Hameed Abd Almonem Abd El Hameed2; Maha Mamdooh Osman 3; Eman Nabil Ghonaim  4; Hanaa R Omar1
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| 1Lecturer of Pediatrics Faculty of Medicine- Benha University | ||||
| 2Professor of Pediatrics Faculty of Medicine - Benha University | ||||
| 3Lecturer of clinical pathology Faculty of Medicine- Helwan University | ||||
| 4Department of Pediatrics, El Bagour General Hospital | ||||
| Abstract | ||||
| Background: Nephrotic syndrome (NS) is characterized by progressive loss of proteins, albumin, & other plasma components of comparable mass in patients who present with a syndrome complex, which includes elevated blood lipid concentrations, urinary lipids, & edema. The study aimed to assess the predictive value of urine Hemopexin concentration in kids with Idiopathic Nephrotic Syndrome in relation to disease recurrence and steroid response. Methods: This was a comparative study that was performed on 40 children attending Pediatric Nephrology unit & outpatient Clinic of Benha University Hospital from August 2022 to February 2023 and 20 apparently healthy control kids who were selected from outpatient clinic. Hemopexin concentrations in urine of all subjects (uHpx) were determined by ELISA. Results: An extremely significant difference in urinary hemopexin concentrations among the groups (F=701.562, p < 0.001). Both children with idiopathic NS and those with relapses have significantly higher hemopexin concentrations in urine in comparison to the control group (P1 | ||||
| Keywords | ||||
| Hemopexin; relapsing nephrotic syndrome; predictor | ||||
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