Circulating miR-30b-5p Level in Plasma as a Potential Biomarker for Early Detection of Breast Cancer | ||
| Benha Medical Journal | ||
| Article 3, Volume 42, Issue 9, September 2025, Pages 23-30 PDF (564.01 K) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/bmfj.2024.294366.2091 | ||
| Authors | ||
| Amal E. Shafie1; Dina Saad Abdelmotaleb2; Mai Ashraf Ramadan* 3; Enas Sebaey Ahmad4 | ||
| 1Clinical and Chemical Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt | ||
| 2Lecturer of Clinical and Chemical Pathology, Faculty of Medicine, Benha University | ||
| 3Clinical and Chemical Pathology Department, Faculty of Medicine, Benha University, Benha, Egypt. | ||
| 4Clinical and Chemical Pathology Department, Faculty of Medicine, Benha University, Egypt | ||
| Abstract | ||
| Purpose: We aimed to assess the rule of plasma miR-30b- 5P as a biomarker for early diagnosis of breast cancer (BrC). Patients and Methods: This case control study was conducted on 50 participants, females, newly diagnosed with breast cancer before receiving any treatment. Subjects were categorized into two groups: Group I (patient group): 35 adults, their age was (53.6 ± 12.20) years, are newly diagnosed BrC before any treatment and Group II (control group): 15 subjects, their age was (47.7 ± 9.59) years, apparently healthy matching age and sex with patients. Results: There is statistically significant difference regarding presence of lesions by Mammogram when compare cases with control (p < .001). And there is a significant elevation in the expression of miR - 30 b - 5p when comparing cases with control group (p < .001). Conclusion: Plasma miR-30b-5P can be used as a biomarker for early diagnosis of BrC. | ||
| Keywords | ||
| MiRNA-30b-5p; Biomarker; Breast Cancer; Mammography | ||
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