Interleukin-18 as a Urinary Biomarker for Diagnosis of Hepatorenal Syndrome in Patients with Decompensated Liver Cirrhosis | ||
| International Journal of Medical Arts | ||
| Volume 6, Issue 7, July 2024, Pages 4684-4691 PDF (1.72 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/ijma.2024.299311.1988 | ||
| Authors | ||
| Amal Elsharnoby1; Ehab Roshdy Ibrahim* 2; Ahmed B. Zaid2; Eman Abdelsameea2; Mohsen Salama2 | ||
| 1Department of Clinical Pathology, National Liver Institute, Faculty of Medicine, El-Menoufia University, Shebin Elkom, Egypt | ||
| 2Department of Hepatology and Gastroenterology, National Liver Institute, Faculty of Medicine, El-Menoufia University, Shebin Elkom, Egypt | ||
| Abstract | ||
| Background: Hepatorenal syndrome [HRS] is a common complication that occurs in people with decompensated cirrhosis and may result in a higher chance of death if not addressed. HRS is a prevalent complication observed in individuals with decompensated cirrhosis which leads to an elevated risk of mortality if left untreated. The aim of the work: To assess the ability of urinary interleukin-18 [IL-18] to be used as potential biomarker for HRS in patients with decompensated liver cirrhosis. Patients and Methods: 120 hospitalized patients with decompensated liver cirrhosis, either with or without HRS were participated in the study. Two groups of patients were identified: 60 patients who had HRS and 60 patients who did not have HRS. Results: Group I exhibited a considerably elevated IL-18 level compared to Group II [57.7±19.7 vs. 19.1±7.93 ng/ mL] [P = 0.001]. At the cutoff point of IL-18, more than 30.1[ng/ mL], it had 96% sensitivity and 90% specificity in detecting HRS patients. Conclusion: Urinary IL-18 may prove to be a valuable biomarker for identifying HRS in patients with decompensated liver cirrhosis, providing valuable insights for diagnosis and management in this clinical setting. | ||
| Keywords | ||
| Child Pugh score; Decompensated liver cirrhosis; Hepatorenal syndrome; Interleukin-18 | ||
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