The Effect of Neoadjuvant Chemotherapy on Her-2 Status in Her-2 Negative Breast Cancer Patients: A Study on Pathological Response | ||||
| Zagazig University Medical Journal | ||||
| Article 26, Volume 30, Issue 1.7, October 2024, Page 3968-3985 PDF (1.47 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/zumj.2024.304607.3478 | ||||
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| Author | ||||
Eman Hussain ALI  
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| Eman H. Khalifa: PhD of Histopathology ,and Cytology Assistance Professor, Laboratory Medicine Dep, Faculty of Applied Medical Science , University of Al Baha, KSA eali@bu.edu.sa imanali72@hotmail.com +966551543109 | ||||
| Abstract | ||||
| Background The impact of neoadjuvant chemotherapy (NAC) on Her-2 status in low Her-2 breast cancer (BC) is not well understood. We assessed the change of Her-2 status in Her2- low and her-2 score 0 in BC patients following NAC. Methods A retrospective study involved a total 469 patients with BC, non metastatic included the study managed in privet hospitals in the Republic of the Sudan. Results A total of 469 patients were eligible and included. Post NAC, 250 (53.3%) patients had a Her-2 score of 0 (176 had unchangeable Her-2 score of 0 and 74 were changed from low Her-2 to Her-2 score 0), while 219 (46.7%) had a low Her-2 (151 had unchangeable low Her-2 and 68 were changed from Her-2 score 0 to low Her-2). Patients with unchanged low Her-2 or changed from low Her-2 score zero had a higher percentage of ER positivity (65.6% and 58.1%) than those with changes from Her-2 score 0 to low (61.7%) or with unchanged Her-2 score 0 (52.8%), respectively. Patients with low Her-2 post-NAC who maintained low Her-2 had higher grade, Ki-67, and ER+ status compared to those whose Her-2 status changed. Patients with a Her-2 score of 0 post-NAC had higher Ki-67 levels and were more likely to be ER+. There was no significant correlation between post-NAC changes in Her-2 status and RCB. Conclusion Changes in low Her2- expression were observed in post-NAC BC patients. Further investigation is needed to recognize the prognostic values of Her-2 changes in low Her-2-BC. | ||||
| Keywords | ||||
| Keywords Low Her-2; Her-2 score 0; breast cancer; neoadjuvant chemotherapy | ||||
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