Evaluation of the Effect of Low-Level Laser Therapy Versus Photodynamic Therapy on the Level of Serum IL-17 and Salivary IL-4 in Patients Suffering from Erosive/Atrophic Oral Lichen Planus: A Case Control Study | ||||
| Egyptian Journal of Chemistry | ||||
| Volume 67, Issue 13, December 2024, Page 2005-2014 PDF (785.38 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2024.296228.9832 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mona Abdallah Sabry   1; Mostafa Esam Gheith2; Amal Ali Hussine3; Amany Mohy Eldeen El Sayed4; Sherihan Hassan Elkady5; Doaa Mohamed Abd El Aziz6
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| 1Researcher in Surgery and Oral Medicine department, Oral and Dental research institute, NRC | ||||
| 2Professor of Laser Applications in Dental Surgeries, National Institute of Laser Enhanced Sciences (NILES), Cairo University, Egypt. | ||||
| 3Associate Professor of Oral Medicine & Periodontology, Faculty of Dentistry, Cairo University, Egypt. | ||||
| 4Assistant Professor of Oral Medicine & Periodontology, Oral and Dental Research Institute, National Research Centre (NRC), Egypt | ||||
| 5Lecturer of Clinical & Chemical Pathology, October University for Modern Sciences and Arts, Egypt. | ||||
| 6Assistant Professor of Clinical & Chemical Pathology, Faculty of Medicine, Ain Shams University, Egypt. | ||||
| Abstract | ||||
| Introduction: One of the most common treatment modalities of oral lichen planus (OLP) is topical corticosteroids (TCS). However, it has several side effects which are harmful to the patients. One such promising treatment modality is low level laser therapy (LLLT) as well as photodynamic therapy (PDT) which are considered safe and reliable in reducing the painful symptoms of the disease with minimal side effects. The inflammatory mediators; cytokines as (IL- 4 & IL- 17) were found to play a crucial role in the pathogenesis of atrophic/erosive OLP. The aim of this study is to investigate and compare the effect of PDT, LLLT & TCS by measuring the pain scale VAS, IL- 4 in saliva and IL- 17 in serum to detect the response of OLP patients to these different modalities. Methods: The study was conducted on 30 patients divided into 3 groups. Each group received either of 3 treatments; PDT, LLLT or TCS, then VAS, salivary IL-4 and serum IL-17 were measured by ELISA at base line, immediately after the first session, at 2 and 4 months from base line to detect the efficiency of each type of treatment. Results: The use of PDT and LLLT were effective and superior to TCS in treatment of OLP in adult patients. Cytokines were reduced in the 3 groups and VAS was markedly reduced by LLLT. No correlation was found between any of the used parameters, this shows that each one of the parameters was efficient on its own in monitoring the effectiveness of the three treatment modalities used. | ||||
| Keywords | ||||
| Keywords: Oral Lichen Planus; Photodynamic Therapy; Low-Level Laser Therapy, IL-4, IL-17, VAS | ||||
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