The potential harmful effect of cyclophosphamide on the placenta in rats
Fadl Barsoum, R., Abdelzaher, W., Abdel_Gaber, S., Abdel- Aziz, A., Mohammed, N., Ibrahim, S. (2024). The potential harmful effect of cyclophosphamide on the placenta in rats. EKB Journal Management System, (), -. doi: 10.21608/mjmr.2024.304622.1748
Rania Rady Fadl Barsoum; Walaa Yehia Abdelzaher; Seham Abdel-Wakeel Abdel_Gaber; Asmaa Abdel- Aziz; Nada Amgad Mohammed; Salwa Abdeltawab Ibrahim. "The potential harmful effect of cyclophosphamide on the placenta in rats". EKB Journal Management System, , , 2024, -. doi: 10.21608/mjmr.2024.304622.1748
Fadl Barsoum, R., Abdelzaher, W., Abdel_Gaber, S., Abdel- Aziz, A., Mohammed, N., Ibrahim, S. (2024). 'The potential harmful effect of cyclophosphamide on the placenta in rats', EKB Journal Management System, (), pp. -. doi: 10.21608/mjmr.2024.304622.1748
Fadl Barsoum, R., Abdelzaher, W., Abdel_Gaber, S., Abdel- Aziz, A., Mohammed, N., Ibrahim, S. The potential harmful effect of cyclophosphamide on the placenta in rats. EKB Journal Management System, 2024; (): -. doi: 10.21608/mjmr.2024.304622.1748

The potential harmful effect of cyclophosphamide on the placenta in rats

Minia Journal of Medical Research
Articles in Press, Accepted Manuscript, Available Online from 26 August 2024  XML
Document Type: Original Article
DOI: 10.21608/mjmr.2024.304622.1748
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Authors
Rania Rady Fadl Barsoum email 1; Walaa Yehia Abdelzaher2; Seham Abdel-Wakeel Abdel_Gaber3; Asmaa Abdel- Aziz4; Nada Amgad Mohammed5; Salwa Abdeltawab Ibrahim6
1Department of medical pharmacology, faculty of medicine , Minia university
2Medical pharmacology department, Faculty of Medicine, Minya University
3Department of medical pharmacology, faculty of medicine, minia University, minia,Egypt.
4Department of Medical Pharmacology , faculty of medicine, Minia university
5department of histology, faculty of medicine, Minia University, Minia, Egypt
6Department of medical pharmacology, Faculty of medicine, Minia university, Minia, Egypt
Abstract
Abstract:

Background & Aim: Placental insufficiency is one of the hazardous complications that may occur during pregnancy leading to adverse pregnancy outcomes. Cyclophosphamide (CYC) is one of the chemotherapeutic drugs that can be used for the treatment of many cancers and autoimmune diseases. One of its indication is the treatment of SLE in pregnant women. The current study aimed to investigate the effect of CYC on the placenta.

Materials and methods: twelve female Wister albino rats were randomly divided into 2 experimental groups. Group 1: control pregnant group; Group 2: pregnant rats received CYC (20 mg/kg, i.p). Placental malondialdehyde (MDA), reduced glutathione (GSH), total antioxidant capacity (TAC), NADP oxidase 4 (NOX4) and caspase-3 were measured. Histological changes were also evaluated.

Key findings: CYC showed a significant decrease in placental TAC but a significant increase in placental MDA, NOX4, and caspase-3.

Conclusion: The current study revealed that CYC has toxic effects on placenta confirmed by inducing oxidative stress, inflammation and apoptosis in placental tissue.
Keywords
Cyclophosphamide; placenta; NOX4
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