The protective Effect of Ocimum basilicum and Melissa officinalis Aqueous Extract on Aluminum -Induced Brain Toxicity in Rats
Metwally Ali, S., H. Negm, S., G. El-Masry, H. (2024). The protective Effect of Ocimum basilicum and Melissa officinalis Aqueous Extract on Aluminum -Induced Brain Toxicity in Rats. EKB Journal Management System, 40(3), 23-42. doi: 10.21608/jhe.2024.376255
Shaimaa Metwally Ali; Shaimaa H. Negm; Hany G. El-Masry. "The protective Effect of Ocimum basilicum and Melissa officinalis Aqueous Extract on Aluminum -Induced Brain Toxicity in Rats". EKB Journal Management System, 40, 3, 2024, 23-42. doi: 10.21608/jhe.2024.376255
Metwally Ali, S., H. Negm, S., G. El-Masry, H. (2024). 'The protective Effect of Ocimum basilicum and Melissa officinalis Aqueous Extract on Aluminum -Induced Brain Toxicity in Rats', EKB Journal Management System, 40(3), pp. 23-42. doi: 10.21608/jhe.2024.376255
Metwally Ali, S., H. Negm, S., G. El-Masry, H. The protective Effect of Ocimum basilicum and Melissa officinalis Aqueous Extract on Aluminum -Induced Brain Toxicity in Rats. EKB Journal Management System, 2024; 40(3): 23-42. doi: 10.21608/jhe.2024.376255

The protective Effect of Ocimum basilicum and Melissa officinalis Aqueous Extract on Aluminum -Induced Brain Toxicity in Rats

مجلة الاقتصاد المنزلي
Volume 40, Issue 3, September 2024, Page 23-42  XML PDF (484.98 K)
Document Type: المقالة الأصلية
DOI: 10.21608/jhe.2024.376255
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Authors
Shaimaa Metwally Ali1; Shaimaa H. Negm2; Hany G. El-Masry1
1Nutrition and Food Science Department, Faculty of Home Economics, Helwan University
2Home Economics Dept., Specific Education Faculty, Port Said University, Egypt
Abstract
A lot of products that are made commercially contain aluminum chloride (AlCl3). Excessive exposure of brain cells to aluminum leads to toxicity by aluminum which enables it to pass through the blood-brain barrier, accumulate in the brain and (Al) may also change brain neurotransmitters and impede the function of antioxidant enzymes which lead to worsen neurological dysfunction and cause brain toxicity. This study aimed to protect and enhance brain cells from harmful effects of (Al3Cl) via utilization herbs are known to have contents of strong antioxidants that scavenge free radicals. Sweet basil and lemon balm contained mimic phenolic compounds and flavonoids such as rosmarinic acid and luteolin. Rats were divided into seven groups: negative control group(normal), positive control group (untreated group), 1 ml sweet basil aqueous extract,2 ml (SBAE),1 ml lemon balm aqueous extract,2 ml (LBAE) and (1+1) (SBAE) and (LABE). The best result in all groups was (1+1) (SBAE) and (LBAE) recorded the highest increase in (FI), (BWG) and (FER). Furthermore, this group recorded an increase in norepinephrine dopamine, serotonin, (HDL), (MDA), (SOD), (CAT) and (GSH). Whereas these groups recorded the lowest reduction in (AST), (ALT), (ALP), (TC), (TG), (LDL), (VLDL), urea nitrogen, creatinine and uric acid. Utilization: dried leaves of lemon balm and sweet basil possess many health benefits so use these herbs for 30 days to enhance many body functions.
Keywords
Brain Toxicity; Oxidative stress; Aluminum chloride; sweet basil; Lemon balm
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