Complete blood count indices as inflammatory markers in diabetic patients with active pulmonary tuberculosis

Zyada, Kholoud MA.; Abdelwahab, Amany E.; Eid, Hoda A.; El-madbouly, Asmaa A.

doi:10.21608/jram.2024.287173.1243

	Complete blood count indices as inflammatory markers in diabetic patients with active pulmonary tuberculosis
Journal of Recent Advances in Medicine
Volume 5, Issue 2, July 2024, Page 111-120 PDF (1.58 MB)
Document Type: Original Article
DOI: 10.21608/jram.2024.287173.1243
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Authors
Kholoud MA. Zyada ¹; Amany E. Abdelwahab²; Hoda A. Eid²; Asmaa A. El-madbouly³
¹Chest Diseases Department, Faculty of Medicine Damietta University, Damietta, Egypt.
²Chest Diseases Department, Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt.
³Clinical pathology Department, Faculty of Medicine for Girls, Cairo, Al-Azhar University, Egypt.
Abstract
Background: The role of hematological indices in follow-up of pulmonary tuberculosis (PTB) has not been extensively investigated. Objectives: To evaluate the role of hematological indices as inflammatory markers in PTB course in diabetes mellitus (DM) and non-diabetes mellitus (NDM) patients. Methodology: The present prospective cohort study included a total of 90 active pulmonary tuberculosis patients. They were grouped into 30 uncontrolled (DM-TB), 30 controlled (DM-TB), and 30 (NDM-TB) patients. All have active smear-positive PTB. The following parameters were reported before starting anti-TB treatment (baseline), and at 1^st, and2^nd months after starting treatment; mean corpuscle volume (MCV), red blood cell distribution width (RDW), mean corpuscle hemoglobin (MCH), mean corpuscle hemoglobin concentration (MCHC), mean platelet volume (MPV),platelet distribution width (PDW),neutrophil-lymphocyte ratio (NLR), monocyte lymphocyte ratio (MLR) and platelet lymphocyte ratio (PLR). Results: the MCV and RDW were significantly higher in the uncontrolled DM-TB group than in the other two groups, and in the controlled DM-TB group than in the NDM-TB group at baseline,1^st and2^nd months. The RDW was significantly decreased from baseline till 2^nd month in the uncontrolled and controlled DM-TB groups. The MPV was significantly lower in uncontrolled DM-TB group than in the other two groups, and in controlled DM-TB group than in the NDM-TB group at baseline, 1^st and 2^nd months. PDW was significantly reduced in uncontrolled and controlled DM-TB groups than in the NDM-TB group at 2^nd month. In the uncontrolled and controlled DM-TB groups, the MPV and PDW were significantly increased during follow-up. The NLR and PLR were significantly higher in uncontrolled DM-TB group than the other two groups and in controlled DM-TB group than in NDM-TB group at 1^st month. MLR was significantly higher in uncontrolled DM-TB group than in the other two groups and in controlled DM-TB group than in NDM-TB group at 1^st and 2^nd months. In uncontrolled DM-TB and controlled DM-TB groups the NLR, PLR, and MLR were decreased during follow-up. Conclusion: The MCV, RDW, MPV, PDW, NLR, PLR and MLR could have an important role in follow-up of PTB in diabetic patients and in predicting treatment outcome.
Keywords
complete blood count indices; tuberculosis; Diabetes Mellitus


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