Ameliorative Effect Of Rosuvastatin On High Fat Diet Induced Nonalcoholic Fatty liver Disease In Adult Male Albino Rats | ||
| Aswan University Medical Journal | ||
| Volume 4, Issue 2, September 2024, Pages 67-79 PDF (1.13 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/aumj.2024.308682.1128 | ||
| Authors | ||
| Amal Taha Abou-Elghait1; Nesreen Mahmoud Abd El-Rady2; Dahia Ahmed Mansour* 3; Asmaa Yossef Ali1 | ||
| 1Depatment of Histology and Cell Biology, Faculty of Medicine, Assuit University | ||
| 2Depatment of Medical physiology, Faculty of Medicine, Assuit University | ||
| 3Depatment of Histology Cell Biology, Faculty of Medicine ,Aswan University | ||
| Abstract | ||
| Abstract Background: Nonalcoholic fatty liver disease (NAFLD) is emerging one of the major causes of chronic liver damage that includes a wide spectrum of liver injury ranging from steatosis to steatohepatitis evolving to fibrosis. Aim of the work:The purpose of our present study is to investigate the role of rosuvastatin in ameliorating the histological changes observed in animal model of HFD induced NAFLD. Materials and Methods: forty adult male albino rats divided into 2 groups:control group, HFD group which divided into 3 groups HFD-control, crestor group and withdrawal group. Results: Our results showed that rosuvastatin significantly ameliorated the histopathological lesions induced by HFD. Furthermore, HFD induced a significant elevation in blood glucose level ,lipid profile, liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)). This was significantly attenuated by rosuvastatin treatment and withdrawal of HFD. Conclusion: These findings indicate that rosuvastatin and withdrawal of HFD possess a marked role in modulation of NAFLD. | ||
| Keywords | ||
| NAFLD; rosuvastatin; HFD | ||
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