Ameliorative Effect Of Rosuvastatin On High Fat Diet Induced Nonalcoholic Fatty liver Disease In Adult Male Albino Rats | ||||
| Aswan University Medical Journal | ||||
| Volume 4, Issue 2, September 2024, Page 67-79 PDF (1.13 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/aumj.2024.308682.1128 | ||||
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| Authors | ||||
Amal Taha Abou-Elghait1; Nesreen Mahmoud Abd El-Rady2; Dahia Ahmed Mansour  3; Asmaa Yossef Ali1
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| 1Depatment of Histology and Cell Biology, Faculty of Medicine, Assuit University | ||||
| 2Depatment of Medical physiology, Faculty of Medicine, Assuit University | ||||
| 3Depatment of Histology Cell Biology, Faculty of Medicine ,Aswan University | ||||
| Abstract | ||||
| Abstract Background: Nonalcoholic fatty liver disease (NAFLD) is emerging one of the major causes of chronic liver damage that includes a wide spectrum of liver injury ranging from steatosis to steatohepatitis evolving to fibrosis. Aim of the work:The purpose of our present study is to investigate the role of rosuvastatin in ameliorating the histological changes observed in animal model of HFD induced NAFLD. Materials and Methods: forty adult male albino rats divided into 2 groups:control group, HFD group which divided into 3 groups HFD-control, crestor group and withdrawal group. Results: Our results showed that rosuvastatin significantly ameliorated the histopathological lesions induced by HFD. Furthermore, HFD induced a significant elevation in blood glucose level ,lipid profile, liver enzymes (alanine aminotransferase (ALT) and aspartate aminotransferase (AST)). This was significantly attenuated by rosuvastatin treatment and withdrawal of HFD. Conclusion: These findings indicate that rosuvastatin and withdrawal of HFD possess a marked role in modulation of NAFLD. | ||||
| Keywords | ||||
| NAFLD; rosuvastatin; HFD | ||||
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