EFFICACY AND PHARMACOKINETICS OF KANAMYCIN IN PSEUDOMONAS ELUORESCENS INFECTED CLARIAS LAZERA FISH
M., A., A., Y., S., A., M., N. (1996). EFFICACY AND PHARMACOKINETICS OF KANAMYCIN IN PSEUDOMONAS ELUORESCENS INFECTED CLARIAS LAZERA FISH. EKB Journal Management System, 44(2), 443-451. doi: 10.21608/vmjg.1996.376554
AMER M.; YONIS A.; ABD EL-AZIZ S.; NAGUIB M.. "EFFICACY AND PHARMACOKINETICS OF KANAMYCIN IN PSEUDOMONAS ELUORESCENS INFECTED CLARIAS LAZERA FISH". EKB Journal Management System, 44, 2, 1996, 443-451. doi: 10.21608/vmjg.1996.376554
M., A., A., Y., S., A., M., N. (1996). 'EFFICACY AND PHARMACOKINETICS OF KANAMYCIN IN PSEUDOMONAS ELUORESCENS INFECTED CLARIAS LAZERA FISH', EKB Journal Management System, 44(2), pp. 443-451. doi: 10.21608/vmjg.1996.376554
M., A., A., Y., S., A., M., N. EFFICACY AND PHARMACOKINETICS OF KANAMYCIN IN PSEUDOMONAS ELUORESCENS INFECTED CLARIAS LAZERA FISH. EKB Journal Management System, 1996; 44(2): 443-451. doi: 10.21608/vmjg.1996.376554

EFFICACY AND PHARMACOKINETICS OF KANAMYCIN IN PSEUDOMONAS ELUORESCENS INFECTED CLARIAS LAZERA FISH

Veterinary Medical Journal (Giza)
Volume 44, Issue 2, April 1996, Pages 443-451    PDF (4.32 M)
Document Type: Original Article
DOI: 10.21608/vmjg.1996.376554
Authors
AMER M.* 1; YONIS A.2; ABD EL-AZIZ S.2; NAGUIB M.2
1Department of Pharmacology, faculty of Vet. Medicine, Cairo Univ.
2Department of Fish Diseases, Animal Health Research Institute, Dokki.
Abstract
 
Efficacy and pharmacokinetics of kanamycin were Studied in P. fluorescens infected Clarias lazera (Nile catfish). The clinical sings of P.fluorescens infection started after 12-24 hours post intraperitoneal inoculation. Kanamycin was injected in a single dose (20 mg/kg b.wt.) in the infected group and another apparently healthy control group. Recovery percent reached 73.33 in the infected fish group after 48 hours® post antibiotic injection Kanamycin was rapidly absorbed after intraperitoneal injection and reached its highest concentration 9.87+0.00059 and 9.20+0.85 µg/ml four hours post injection in normal and infected fish groups, respectively. Kanamycin was rapidly absorbed in infected fish ( a = 0.2726 + 0.002h"! and ty < & = 2.69 + 0.16 min.) than in normal fish a= 0.20420.009h"! and ty, a= 3.4420.14 min.). Kanamycin was rapidly excreted in infected fish with ty 5 B= 5.63+0.3764 hrs than in normal fish with tp 5 B= 7.55+1988 hrs. The interval between doses was short in infected fish 44.28 hrs than in normal fish 55.85hrs.
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