PHARM ACOKINETIC BEHAVIOR OF PEFLOXACIN IN LACTATING GOAT | ||||
| Veterinary Medical Journal (Giza) | ||||
| Volume 48, Issue 4, October 2000, Page 467-477 PDF (3.18 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/vmjg.2000.376558 | ||||
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| Authors | ||||
| A ABD EL-ATY1; A GOUDAH2 | ||||
| 1Department of Pharmacology, Faculty of veterinary medicine cairo university | ||||
| 2Department of Pharmacology, Faculty of veterinary medicine Cairo university | ||||
| Abstract | ||||
| Pefloxacin (PEL) was administered intravenous-ly (iv) and intramuscularly (im) at a dose rate of ‘Omg kg"! b.wt. to five healthy,weighing 18-22 kg. Blood, urine lactating goats and milk samPles Were collected at precise time intervals and ne “oncentrations were determined by using a microbiological assay method. The pharmacoki- parameter Were estimated using routine equation. A two Compartment Open model best described the decrease of pefloxacin concentration in serum after intravenous injection. The drug was rapidly and widely distributed with distribution half life (tla of 0.097 + 0.012 h and steady state volume of distribution (Vdss) 5.144 +0.206 L kg. PEL was rapidly absorbed after im injection with an absorbtion halflife of 0.315+0.016 h. the peak serum concentration Cmax was 0.862+ 0.083 mg.ml at T max 0.75 h. the systemic bioavailability after im injection was 70.632+1.130% and the serum protien bound fraction was 9.756+ 1.573%. the drug was detected in milk and urine for 12 and 72 h, respectinely. | ||||
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