Development of a Highly sensitive Methionine Sensor based on Copper Phthalocyanine and Gold Nanoparticles-Modified Carbon Paste Electrode
Mohamed, H., Radowan, A. (2025). Development of a Highly sensitive Methionine Sensor based on Copper Phthalocyanine and Gold Nanoparticles-Modified Carbon Paste Electrode. EKB Journal Management System, 68(4), 157-165. doi: 10.21608/ejchem.2024.306703.10070
Hany M. Mohamed; Abdellatef A. A. Radowan. "Development of a Highly sensitive Methionine Sensor based on Copper Phthalocyanine and Gold Nanoparticles-Modified Carbon Paste Electrode". EKB Journal Management System, 68, 4, 2025, 157-165. doi: 10.21608/ejchem.2024.306703.10070
Mohamed, H., Radowan, A. (2025). 'Development of a Highly sensitive Methionine Sensor based on Copper Phthalocyanine and Gold Nanoparticles-Modified Carbon Paste Electrode', EKB Journal Management System, 68(4), pp. 157-165. doi: 10.21608/ejchem.2024.306703.10070
Mohamed, H., Radowan, A. Development of a Highly sensitive Methionine Sensor based on Copper Phthalocyanine and Gold Nanoparticles-Modified Carbon Paste Electrode. EKB Journal Management System, 2025; 68(4): 157-165. doi: 10.21608/ejchem.2024.306703.10070

Development of a Highly sensitive Methionine Sensor based on Copper Phthalocyanine and Gold Nanoparticles-Modified Carbon Paste Electrode

Egyptian Journal of Chemistry
Volume 68, Issue 4, April 2025, Page 157-165  XML PDF (579.55 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2024.306703.10070
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Authors
Hany M. Mohamed1; Abdellatef A. A. Radowan email orcid 2
1Chemistry Department, Faculty of Science, Taif University.
2Applied Organic Chemistry department, Chemical Industries Research Institute, National Research Center
Abstract
A novel electrochemical sensor for the sensitive and selective detection of methionine (Met) has been developed, utilizing copper (II)phthalocyanine (CuPc)-gold nanoparticles (AuNPs)– modified carbon paste electrode (CPE). This sensor was thoroughly characterized using a combination of techniques including cyclic voltammetry (CV), and electrochemical impedance spectroscopy (EIS). Cyclic voltammetry studies revealed a significant enhancement in the electrochemical behavior of methionine at the CuPc–AuNPs modified carbon paste electrode (CuPc-AuNPs/CPE) compared to both the unmodified carbon paste electrode and modified CuPc-CPE. The increase of the anodic redox signal for methionine was credited to a catalytic effect of AuNPs. This effect was examined using three different CPEs with varying concentrations of Au nanoparticles (0.03, 0.06, and 0.12 wt.%), while each electrode contained a fixed amount of CuPc (0.6 wt%). The sensor fabricated with 0.06% AuNPs exhibited superior sensitivity, as evidenced by differential pulse voltammetry analysis. This sensor exhibited an analytical range of 2.0 –150 µM and a limit of detection (LOD) of 0.5 µM. The developed sensor was successfully applied for the determination of methionine in pharmaceutical preparations.
Keywords
Methionine; phthalocyanine; electrochemical sensor; gold nanoparticles; cyclic voltammetry; differential pulse voltammetry
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