Relation between Red Blood Cells and Platelets Related Indices and Disease Activity in Patients with Juvenile Idiopathic Arthritis. | ||
| Zagazig University Medical Journal | ||
| Article 19, Volume 30, Issue 9, December 2024, Pages 4482-4493 PDF (1.16 M) | ||
| Document Type: Original Article | ||
| DOI: 10.21608/zumj.2024.309028.3501 | ||
| Authors | ||
| Sama Khaled Bayoumy* 1; Essam Tawfeak Atwa1; Hesham mohamed Omar2; Doaa Elsayed Kamal3 | ||
| 1Rheumatology and rehabilitation faculty of medicine Zagazig University | ||
| 2Clinical pathology department, faculty of medicine, zagazig university, sharkia | ||
| 3Lecturer of Rheumatology and Rehabiitation, Zagazig University. | ||
| Abstract | ||
| Abstract Background Red blood cells (RBCs) and platelets have been linked to inflammation in various rheumatological illnesses. As a result, the purpose of the current research was to investigate the association between each of the RBC- and platelet-related parameters and disease activity in JIA patients, as well as to compare these indices between JIA patients and normal children. Methods A case-control study included 88 subjects, 44 in each group (JIA & control). The variations in platelet indices between normal and JIA children were documented. The associations between CBC-related parameters and disease activity, disease subtype, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) were determined. Results JIA patients had significantly higher hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin concentration (MCHC), platelets (PCT), HB to platelets (HPR), mean corpuscular hemoglobin (MCH) platelets count, platelets to lymphocytes ratio (PLR) & WBC count and lower mean platelet volume (MPV), RBCs to platelet ratio (RPR), and compared to healthy children (P <0.05). Active JIA patients exhibited significantly lower levels of MPV, Hb, MCH, RPR, and HPR and significantly higher platelets than inactive JIA patients’ children (P <0.05). Both CRP & ESR levels showed significant negative correlations with MCHC, hemoglobin levels, MCH, RPR, and HPR in JIA patients (P<0.05). Meanwhile, ESR levels revealed a strong positive correlation with platelet count and PCT, and CRP levels revealed a strong positive correlation with platelet count only. | ||
| Keywords | ||
| JIA; RBCs; platelets; MPV; CBC indices | ||
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