EFFECT OF THE FUNGICIDE (TRI-MILTOX FORT) ON SOME REPRODUCTIVE ASPECTS IN FEMALE RATS | ||||
| Veterinary Medical Journal (Giza) | ||||
| Volume 46, Issue 4, October 1998, Page 833-847 PDF (4.94 MB) | ||||
| DOI: 10.21608/vmjg.1998.377377 | ||||
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| Authors | ||||
| W.M. AHMED* ; H. M. DESOUKY; H. A. AMER KARIMA; G.M. MAHMOUD; Y.F. AHMED | ||||
| Department of Animal Reproduction and Artificial Insemination, National Research Centre, Cairo, Egypt. | ||||
| Abstract | ||||
| Two main experiments were carried out to investigate the effect of chronic low dose oral administration of the fungicide Tri-Miltox Fort (TMF) on female reproduction in rats. In the 1st experiment, 24 non pregnant mature female rats were divided into 2 equal groups, the 1st one was kept as a control while . the 2nd one was given water containing 0.5 g/liter of the fungicide for a period of 2 months, thereafter, half of each group was sacrificed and the remaining half was allowed to drink tap water only for a period of another month then sacrificed. Blood and tissue samples were collected and subjected to biochemical, pathological and chromosomal studies.in the the 2nd experiment, 14 pregnant rats, were divided into 2 groups, the 1st one (N=6) was kept as a control while, the 2nd one (N=8) Received the above mentioned dose of the fungicidal during days 6-15 of gestation then killed on 19 and foetuses were examined for morphological as well as visceral and skeletal malformations. Results indicated that exposure of female rats to the fungicide TMF induced reduction of fertility, ovarian quiescence, adverse changes in serum biochemistry compared to control group. At the sametime, this fungicide induced pronounced pathological changes in ovaries, uteruses and thryroid glands together with different types of numerical and structural chromosomal aberrations in bone marow cells of exposed animals. All the aforementioned change did not return back to normal status UP to one month after cessation of TMF administration. Exposure of pregnant rats to this fungicide Leads to reduction of foetal weights as well as skeletal and visceral malformations. In conclusion, exposure to the fungicidal TMF Induced sever irreversible adverse, biochemical, pathological chromosomal and teratogenic changes with consequent impairment of the reproductive function in female rats. | ||||
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